Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues.
Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues.
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DOI：
10.1054/bjoc.2000.1396
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发表时间：
2000-10
影响因子：
8.8
通讯作者：
Sugimachi K
中科院分区：
文献类型：
--
作者：
Akagi K;Ikeda Y;Miyazaki M;Abe T;Kinoshita J;Maehara Y;Sugimachi K
血管内皮生长因子-C(VEGF-C)具有特异性地诱导淋巴管生成的功能。我们探讨了结直肠癌组织中血管内皮生长因子-C的表达与临床病理特征的关系。应用免疫组织化学方法检测99例结直肠癌原发灶和18例转移淋巴结中血管内皮生长因子-C的表达。逆转录-聚合酶链式反应(RT-PCR)检测血管内皮细胞生长因子-C(VEGF-C)的表达。血管内皮生长因子-C的表达与肿瘤的淋巴转移、淋巴结转移和侵袭深度有关。另一方面，与患者性别、组织学类型、静脉受累和肝转移无关。在转移性淋巴结中的表达与在原发灶中的表达基本一致。VEGF-C阳性组生存期短于阴性组，但差异无统计学意义。RT-PCR结果显示，血管内皮生长因子C基因的表达与血管内皮生长因子C蛋白的表达密切相关。血管内皮生长因子-C可能在结直肠癌淋巴扩散中起重要作用。©2000癌症研究活动
Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorectal cancer patients was examined immunohistochemically. To verify VEGF-C mRNA expression, reverse transcriptase-polymerase chain reaction (RT-PCR) was carried out. The expression of VEGF-C correlated with lymphatic involvement, lymph nodes metastasis, and depth of invasion. On the other hand, correlations were nil with regard to gender of the patients, histologic type, venous involvement, and liver metastasis. The expression of VEGF-C in metastatic lymph nodes was fairly consistent with this expression in the primary tumour. Survival time was shorter for VEGF-C positive groups than for VEGF-C negative ones, but with no statistically significant difference. RT-PCR findings revealed that the expression of VEGF-C mRNA correlated mostly with that of VEGF-C protein expression. VEGF-C may play an important role in lymphatic spread of colorectal cancer. © 2000 Cancer Research Campaign
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影响因子：
2.6
作者：
HERMANEK, P
通讯作者：
HERMANEK, P
影响因子：
9.6
作者：
CHAPUIS, PH;DENT, OF;COLQUHOUN, K
通讯作者：
COLQUHOUN, K
影响因子：
8
作者：
Landgren, E;Schiller, P;Claesson-Welsh, L
通讯作者：
Claesson-Welsh, L
DOI：
10.1007/bf00312379
发表时间：
1995-01-01
期刊：
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
影响因子：
--
作者：
TSUCHIYA, A;ANDO, Y;ABE, R
通讯作者：
ABE, R
影响因子：
6.7
作者：
Wartiovaara, U;Salven, P;Palotie, A
通讯作者：
Palotie, A