Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions.
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions.
复制标题
DOI：
10.3389/fnmol.2016.00086
复制
发表时间：
2016
影响因子：
4.8
通讯作者：
Orellana JA
中科院分区：
文献类型：
--
作者：
Gajardo-Gómez R;Labra VC;Orellana JA
在生理条件下，小胶质细胞采用与抗炎和神经营养因子的产生相关的静息表型。在应对各种各样的侮辱，这些细胞转移到一个激活的表型，这是必要的适当恢复脑内稳态。然而，当威胁的强度相对较高时，小胶质细胞活化会阻止损伤的进展，而不是提供保护，对神经元存活具有潜在的重大后果。小胶质细胞和其他脑细胞（包括星形胶质细胞和神经元）之间的协调相互作用对于脑实质中及时和最佳炎症反应的发展至关重要。组织同步化部分是由连接蛋白和泛连接蛋白介导的，它们是形成不同质膜通道以与相邻细胞通信的蛋白质家族。间隙连接通道（在脊椎动物中仅由连接蛋白形成）连接接触细胞的细胞质以协调电耦合和代谢耦合。半通道（HC）和泛连接子（分别由连接蛋白和泛连接蛋白形成）连通细胞内和细胞外区室，并作为离子和小分子交换的扩散途径。在这篇综述文章中，我们讨论了现有的证据有关的连接蛋白和泛连接蛋白为基础的通道在小胶质细胞的功能表达和调节，以及它们对小胶质细胞功能和功能障碍的贡献。具体来说，我们专注于这些通道在小胶质细胞与小胶质细胞，小胶质细胞与星形胶质细胞和神经元与小胶质细胞的相互作用在发炎的大脑中的可能影响。
Under physiological conditions, microglia adopt a resting phenotype associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, these cells shift to an activated phenotype that is necessary for the proper restoration of brain homeostasis. However, when the intensity of a threat is relatively high, microglial activation worsens the progression of damage rather than providing protection, with potentially significant consequences for neuronal survival. Coordinated interactions among microglia and other brain cells, including astrocytes and neurons, are critical for the development of timely and optimal inflammatory responses in the brain parenchyma. Tissue synchronization is in part mediated by connexins and pannexins, which are protein families that form different plasma membrane channels to communicate with neighboring cells. Gap junction channels (which are exclusively formed by connexins in vertebrates) connect the cytoplasm of contacting cells to coordinate electrical and metabolic coupling. Hemichannels (HCs) and pannexons (which are formed by connexins and pannexins, respectively) communicate the intra- and extracellular compartments and serve as diffusion pathways for the exchange of ions and small molecules. In this review article, we discuss the available evidence concerning the functional expression and regulation of connexin- and pannexin-based channels in microglia and their contributions to microglial function and dysfunction. Specifically, we focus on the possible implications of these channels in microglia-to-microglia, microglia-to-astrocyte and neuron-to-microglia interactions in the inflamed brain.
登录
查看更多内容
DOI：
10.1073/pnas.2233464100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Bruzzone, R;Hormuzdi, SG;Monyer, H
通讯作者：
Monyer, H
DOI：
10.1073/pnas.1009382107
发表时间：
2010-08-03
影响因子：
11.1
作者：
Burra, Sirisha;Nicolella, Daniel P.;Jiang, Jean X.
通讯作者：
Jiang, Jean X.
影响因子：
4
作者：
Braet, K;Vandamme, W;Leybaert, L
通讯作者：
Leybaert, L
影响因子：
3.7
作者：
Ayna G;Krysko DV;Kaczmarek A;Petrovski G;Vandenabeele P;Fésüs L
通讯作者：
Fésüs L
影响因子：
9.9
作者：
Bugiani, M.;Al Shahwan, S.;Zeviani, M.
通讯作者：
Zeviani, M.