The protective effect of early dietary fat consumption on Alzheimer's disease-related pathology and cognitive function in mice.
The protective effect of early dietary fat consumption on Alzheimer's disease-related pathology and cognitive function in mice.
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DOI：
10.1002/trc2.12173
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Norris EH
中科院分区：
文献类型：
--
作者：
Amelianchik A;Merkel J;Palanisamy P;Kaneki S;Hyatt E;Norris EH
肥胖可能影响阿尔茨海默病（AD）的发病机制，但关于这一主题的许多出版物有不一致的结果和结论。我们的研究检查了改变高脂饮食（HFD）消耗时间对转基因Tg6799 AD小鼠中AD相关病理学和认知的影响。在严重AD病理学之前，在3月龄或之前开始喂食HFD对AD小鼠具有保护作用：减少细胞外淀粉样蛋白β（Aβ）沉积，减少纤维蛋白原外渗到脑实质中，并改善认知功能。然而，将HFD消耗延迟到6个月大，此时AD病理学无处不在，降低了AD小鼠的这些保护作用。总的来说，我们证明了食用HFD的时间轴可能在膳食脂肪如何影响AD发病机制和认知功能方面发挥重要作用。
It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions. Our study examined the effect of varying the timing of high‐fat diet (HFD) consumption on AD‐related pathology and cognition in transgenic Tg6799 AD mice. HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice: reduced extracellular amyloid beta (Aβ) deposition, decreased fibrinogen extravasation into the brain parenchyma, and improved cognitive function. However, delaying HFD consumption until 6 months of age, when AD pathology is ubiquitous, reduced these protective effects in AD mice. Overall, we demonstrate that the timeline of HFD consumption may play an important role in how dietary fats affect AD pathogenesis and cognitive function.
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影响因子：
--
作者：
Mitchell AS;Czajkowski R;Zhang N;Jeffery K;Nelson AJD
通讯作者：
Nelson AJD
影响因子：
16.2
作者：
Cortes-Canteli, Marta;Paul, Justin;Norris, Erin H.;Bronstein, Robert;Ahn, Hyung Jin;Zamolodchikov, Daria;Bhuvanendran, Shivaprasad;Fenz, Katherine M.;Strickland, Sidney
通讯作者：
Strickland, Sidney
影响因子：
7.8
作者：
Elhaik Goldman S;Goez D;Last D;Naor S;Liraz Zaltsman S;Sharvit-Ginon I;Atrakchi-Baranes D;Shemesh C;Twitto-Greenberg R;Tsach S;Lotan R;Leikin-Frenkel A;Shish A;Mardor Y;Schnaider Beeri M;Cooper I
通讯作者：
Cooper I
影响因子：
4.2
作者：
Cortes-Canteli M;Mattei L;Richards AT;Norris EH;Strickland S
通讯作者：
Strickland S
DOI：
10.1073/pnas.1010373107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Ahn, Hyung Jin;Zamolodchikov, Daria;Strickland, Sidney
通讯作者：
Strickland, Sidney