Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.
Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.
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DOI：
10.1016/j.celrep.2021.110183
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发表时间：
2022-01-04
期刊：
影响因子：
8.8
通讯作者：
Hall RA
中科院分区：
文献类型：
--
作者：
Kumwenda P;Cottier F;Hendry AC;Kneafsey D;Keevan B;Gallagher H;Tsai HJ;Hall RA
白色念珠菌是泌尿生殖道的寄生虫，也是外阴阴道念珠菌病（VVC）的主要病因。增加循环雌激素水平的因素，如怀孕，口服避孕药的使用和激素替代疗法使女性易患VVC，但其原因在很大程度上尚不清楚。在这里，我们研究如何适应C。雌激素影响真菌宿主-病原体相互作用。雌激素通过使C.白念珠菌，以避免先天免疫系统的行动。雌激素诱导的先天性免疫逃避是通过增强真菌细胞表面人补体调节蛋白H因子的获得来抑制调理吞噬而介导的。雌激素诱导的因子H积累依赖于真菌细胞表面蛋白Gpd 2。这种感知途径的发现可能为解释与真菌感染相关的性别偏见铺平道路，并可能为改善女性健康提供另一种方法。雌激素通过降低吞噬作用促进白念珠菌的毒力。雌激素诱导的白色念珠菌先天性免疫逃避。GPD 2的过表达促进了白色念珠菌的毒力。雌激素水平高的女性患由白色念珠菌引起的生殖器鹅口疮的风险增加。Kumwenda等人显示C.在雌激素中生长的白色念珠菌不能被白色血细胞有效识别和杀死。这种降低的免疫识别可能使C。白色念珠菌增殖并引起感染。
Candida albicans is a commensal of the urogenital tract and the predominant cause of vulvovaginal candidiasis (VVC). Factors that increase circulatory estrogen levels such as pregnancy, the use of oral contraceptives, and hormone replacement therapy predispose women to VVC, but the reasons for this are largely unknown. Here, we investigate how adaptation of C. albicans to estrogen impacts the fungal host-pathogen interaction. Estrogen promotes fungal virulence by enabling C. albicans to avoid the actions of the innate immune system. Estrogen-induced innate immune evasion is mediated via inhibition of opsonophagocytosis through enhanced acquisition of the human complement regulatory protein, Factor H, on the fungal cell surface. Estrogen-induced accumulation of Factor H is dependent on the fungal cell surface protein Gpd2. The discovery of this hormone-sensing pathway might pave the way in explaining gender biases associated with fungal infections and may provide an alternative approach to improving women's health. Estrogen promotes the virulence of Candida albicans by reducing phagocytosis Estrogen-adapted C. albicans binds more Factor H on its cell surface Estrogen-induced innate immune evasion of C. albicans is dependent on Gpd2 Overexpression of GPD2 promotes the virulence of C. albicans Women with high estrogen levels have an increased risk of developing genital thrush caused by Candida albicans. Kumwenda et al. show that C. albicans grown in estrogen is not recognized and killed efficiently by white blood cells. This reduced immune recognition could enable C. albicans to proliferate and cause infection.
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影响因子：
3.6
作者：
Hall RA
通讯作者：
Hall RA
影响因子：
7.3
作者：
Dasari P;Shopova IA;Stroe M;Wartenberg D;Martin-Dahse H;Beyersdorf N;Hortschansky P;Dietrich S;Cseresnyés Z;Figge MT;Westermann M;Skerka C;Brakhage AA;Zipfel PF
通讯作者：
Zipfel PF
影响因子：
28.3
作者：
Ballou ER;Avelar GM;Childers DS;Mackie J;Bain JM;Wagener J;Kastora SL;Panea MD;Hardison SE;Walker LA;Erwig LP;Munro CA;Gow NA;Brown GD;MacCallum DM;Brown AJ
通讯作者：
Brown AJ
影响因子：
--
作者：
Cheng, G;Yeater, KM;Hoyer, LL
通讯作者：
Hoyer, LL
影响因子：
3
作者：
Dennison, PMJ;Ramsdale, M;Brown, AJP
通讯作者：
Brown, AJP