Endocrine therapy in prostate cancer: time for reappraisal of risks, benefits and cost-effectiveness?
Endocrine therapy in prostate cancer: time for reappraisal of risks, benefits and cost-effectiveness?
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DOI：
10.1038/bjc.2012.523
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发表时间：
2013-01-15
影响因子：
8.8
通讯作者：
Rosario, D. J.
中科院分区：
文献类型：
--
作者：
Bourke, L.;Kirkbride, P.;Hooper, R.;Rosario, A. J.;Chico, T. J. A.;Rosario, D. J.
在首次描述手术去势的益处后的70年中，尽管药物治疗（例如卡巴他赛、恩杂鲁胺、阿比特龙）取得了进展，但雄激素剥夺治疗（ADT）仍然是晚期前列腺癌治疗的基石。然而，随着越来越多的男性接受PSA检测，这种疾病被诊断得更早，ADT的成本，不确定的生存益处和相关风险，已经急剧上升。有效的新型药物的临床研究已经显示出晚期疾病的生存益处，但治疗的时机，风险和成本效益仍然存在争议。随着新药物进入临床实践，全面的研究策略对于优化获益同时最大限度地减少危害至关重要。
In the 70 years following the first description of the benefits of surgical castration, despite advances in medical therapy e.g. cabazitaxel, enzalutamide, abiraterone, androgen deprivation therapy (ADT) remains the cornerstone of treatment for advanced prostate cancer. However, with increasing numbers of men undergoing PSA testing, the disease is being diagnosed earlier and the costs of ADT, with uncertain survival benefits and associated risks, have risen dramatically. Clinical studies of potent novel agents have shown survival benefits in advanced disease, but timing, risks and cost-effectiveness of treatment remain controversial. As new agents enter clinical practice, a comprehensive research strategy is essential to optimise benefits whilst minimising harm.
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影响因子：
158.5
作者：
Scher, Howard I.;Fizazi, Karim;de Bono, Johann S.
通讯作者：
de Bono, Johann S.
DOI：
10.3322/caac.20061
发表时间：
2010-05
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Levine GN;D'Amico AV;Berger P;Clark PE;Eckel RH;Keating NL;Milani RV;Sagalowsky AI;Smith MR;Zakai N;American Heart Association Council on Clinical Cardiology and Council on Epidemiology and Prevention, the American Cancer Society, and the American Urological Association
通讯作者：
American Heart Association Council on Clinical Cardiology and Council on Epidemiology and Prevention, the American Cancer Society, and the American Urological Association
影响因子：
5.7
作者：
Malkin, Chris J.;Pugh, Peter J.;Channer, Kevin S.
通讯作者：
Channer, Kevin S.
DOI：
10.1093/jnci/djp404
发表时间：
2010-01-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Keating, Nancy L.;O'Malley, A. James;Smith, Matthew R.
通讯作者：
Smith, Matthew R.
影响因子：
45.3
作者：
Roach, Mack, III;Bae, Kyounghwa;Pilepich, Miljenko V.
通讯作者：
Pilepich, Miljenko V.