Using crowdsourcing to study the differential effects of cross-drug withdrawal for cigarettes and opioids in a behavioral economic demand framework.
Using crowdsourcing to study the differential effects of cross-drug withdrawal for cigarettes and opioids in a behavioral economic demand framework.
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DOI：
10.1037/pha0000558
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发表时间：
2022-08
影响因子：
2.3
通讯作者：
Koffarnus, Mikhail N.
中科院分区：
文献类型：
--
作者：
Rzeszutek, Mark J.;Gipson-Reichardt, Cassandra D.;Kaplan, Brent A.;Koffarnus, Mikhail N.
在使用处方或娱乐性阿片类药物的人群中，吸烟率明显高于一般人群。假设阿片类药物和尼古丁之间的神经药理学相互作用可能有助于这种多物质使用模式，特别是在戒断期间。然而，很少有研究检查一种物质的戒断如何影响另一种物质的消耗（即交叉药物戒断效应）。行为经济学需求任务（例如，假设的购买任务）可以用来快速评估药物的价值。众包是一种方便的工具，可以初步了解物质评估的不同过程，否则这些过程可能是不可能或难以研究的。本研究的目的是初步研究假设戒断香烟和阿片类药物对先前有戒断经历的多物质使用者消费这些药物的影响。报告每天吸烟和至少每月使用阿片类药物的亚马逊机械土耳其工人在不同的戒断条件下完成了一系列假设的阿片类药物和香烟的购买任务。当戒断任何一种药物时，对两种药物价格的敏感性下降，表明由于交叉戒断药物的影响，香烟和阿片类药物的药物价值更高。尼古丁和阿片类药物依赖严重程度、冲动选择和风险也与药物购买呈正相关。
Smoking rates among those who use prescribed or recreational opioids is significantly higher than the general population. Hypothesized neuropharmacological interactions between opioids and nicotine may contribute to this pattern of polysubstance use, especially during withdrawal. However, little research has examined how withdrawal of one substance may affect the consumption of the other (i.e., cross-drug withdrawal effects). Behavioral economic demand tasks (e.g., hypothetical purchase tasks) can be used to quickly assess the value of a drug. Crowdsourcing can be a convenient tool to gain preliminary insight into different processes in substance valuation that may otherwise be impossible or prohibitively difficult to study. The purpose of the current study was to provide a preliminary examination of the effects of hypothetical withdrawal of cigarettes and opioids on the consumption of those drugs among polysubstance users with previous withdrawal experience. Amazon Mechanical Turk workers who reported daily smoking and at least monthly opioid use completed a series of hypothetical purchase tasks for doses of opioids and cigarettes under various withdrawal conditions. Sensitivity to price of both drugs decreased when under withdrawal for either, indicating a higher drug value of cigarettes and opioids due to effects of cross-drug withdrawal. Nicotine and opioid dependence severity, impulsive choice, and riskiness were also positively related to drug purchasing.
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DOI：
10.1111/add.13535
发表时间：
2017-01
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Amlung M;Vedelago L;Acker J;Balodis I;MacKillop J
通讯作者：
MacKillop J
影响因子：
3.4
作者：
Gass, Julie C.;Motschman, Courtney A.;Tiffany, Stephen T.
通讯作者：
Tiffany, Stephen T.
影响因子：
25.8
作者：
Higgins, Stephen T.;Heil, Sarah H.;Tursi, Lauren
通讯作者：
Tursi, Lauren
影响因子：
2
作者：
Kaplan, Brent A.;Franck, Christopher T.;Koffarnus, Mikhail N.
通讯作者：
Koffarnus, Mikhail N.
影响因子：
6
作者：
Hsu, Douglas J.;McCarthy, Ellen P.;Mukamal, Kenneth J.
通讯作者：
Mukamal, Kenneth J.