Age- and sex-dependent change in stratum corneum sphingolipids
Age- and sex-dependent change in stratum corneum sphingolipids
复制标题
角质层鞘脂的年龄和性别依赖性变化
DOI：
--
复制
发表时间：
2004
影响因子：
3
通讯作者：
H. Tagami
中科院分区：
文献类型：
--
作者：
M. Denda;J. Koyama;J. Hori;I. Horii;M. Takahashi;M. Hara;H. Tagami
我们测量了 26 名男性和 27 名女性的六种角质层鞘脂种类（神经酰胺 1-6），发现仅在不同年龄组的女性受试者中，其百分比组成存在显着变化。从青春期前到成年，神经酰胺 1 和 2 显着增加，而神经酰胺 3 和 6 相应减少。此后，神经酰胺 2 与总鞘脂的比率随着年龄的增长而下降，而神经酰胺 3 则增加。老龄化人口中的这种变化模式与通过胶带剥离实验诱导的鳞状皮肤中观察到的变化模式不同。目前的结果表明女性激素对角质层鞘脂的组成有显着影响。此外，炎症皮肤鳞屑和老化皮肤鳞屑之间角质层脂质鞘脂组成的不同变化模式也表明表皮鞘脂生物合成受到表皮增殖活性的影响。
We measured six stratum corneum sphingolipid species (ceramides 1–6) in 26 males and 27 females, and found a significant change in their percentage composition only among female subjects of different age groups. There was a significant increase in ceramide 1 and 2 with a corresponding decrease in ceramide 3 and 6 from prepubertal age to adulthood. Thereafter the ratio of ceramide 2 to total sphingolipids decreased with age in contrast to ceramide 3 which showed an increase. Such a pattern of change in the aging population is different from that observed in scaly skin experimentally induced by tape stripping. The present results suggest a significant influence of female hormones on the composition of stratum corneum sphingolipids. Moreover, the different patterns of change in sphingolipid composition of stratum corneum lipids between scales from inflammatory skin and those from aged skin also suggest that epidermal biosynthesis of sphingolipids is influenced by epidermal proliferative activity.
来自人类角质层和粉刺的神经酰胺的成分。
DOI：
10.1111/1523-1747.ep12265510
发表时间：
1985
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Wertz,PW;Miethke,MC;Long,SA;Strauss,JS;Downing,DT
通讯作者：
Downing,DT
猪表皮神经酰胺：结构测定。
影响因子：
6.5
作者：
Wertz,PW;Downing,DT
通讯作者：
Downing,DT