Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post-pandemic period.
Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post-pandemic period.
复制标题
青少年和成人流感肺炎：大流行后时期甲型（H1N1）pdm09和甲型（H3N2）流感的同时比较
DOI：
10.1111/crj.12056
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Cao B
中科院分区：
文献类型：
--
作者：
Yang SQ;Qu JX;Wang C;Yu XM;Liu YM;Cao B
甲型H1N1流感pdm 09与普通季节性流感的特征比较对于临床管理和流行病学研究都具有重要意义。然而，对大流行后时期大流行性流感和季节性流感之间的差异知之甚少。本研究的目的是调查流感后时期甲型H1N1流感pdm 09肺炎和季节性甲型H3 N2流感肺炎患者的临床和免疫应答差异。在流感大流行后第一个流感季节，对北京市社区获得性肺炎成人网络中甲型H1N1 pdm 09和甲型H3 N2流感患者的临床特征和急性期炎症反应进行比较。甲型（H1N1）pdm 09流感肺炎患者的平均年龄与甲型（H3 N2）肺炎患者接近（51 ± 20 vs 53 ± 16，平均值±标准差，岁），但往往患有更多基础疾病（32.8% vs 10%，P = 0.036）。两组患者的临床特征相似，但在肺炎严重程度指数（PSI）评分、重症监护室入住率和病死率方面无统计学差异，但A（H1N1）pdm 09队列患者的血中天冬氨酸转氨酶、乳糖酶脱氢酶水平高于A（H3 N2）队列（P = 0.006，0.018），发热持续时间也较A（H3 N2）队列长。A（H1N1）pdm 09队列中白细胞介素（IL）-10和IL-12（p70）水平较高（分别为P = 0.031，0.047）。在大流行后的第一个流感季节，甲型（H1N1）pdm 09肺炎患者表现出与甲型（H3 N2）肺炎相似的临床特征，但疾病严重程度略高，全身炎症反应更强。
Comparisons of the characteristics between the influenza A (H1N1) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post-pandemic period are poorly understood. The aim of our research was to investigate clinical and immune response differences between patients with influenza A (H1N1) pdm09 pneumonia and seasonal influenza A (H3N2) pneumonia in the post-pandemic period. During the first flu season in post-pandemic period, patients from Beijing Network for Adult Community-Acquired Pneumonia present A (H1N1) pdm09 or A (H3N2) influenza were compared concurrently in the aspects of clinical characteristics and inflammatory profile in acute phase. Patients with A (H1N1) pdm09 influenza pneumonia showed a close mean age to A (H3N2) pneumonia (51 ± 20 vs 53 ± 16, mean ± standard deviation, years) but tended to have more underlying diseases (32.8% vs 10%, P = 0.036). Although clinical characteristics were similar, no statistical difference were found in pneumonia severity index (PSI) score or intensive care unit admission rate or mortality, patients in A (H1N1) pdm09 cohort present higher levels of aspartate aminotransferase, lactase dehydrogenase (P = 0.006, 0.018, respectively) in blood and also longer duration of fever than A (H3N2) cohort. Levels of interleukin (IL)-10 and IL-12 (p70) were higher in A (H1N1) pdm09 cohort (P = 0.031, 0.047, respectively). During the first post-pandemic flu season, patients with the A (H1N1) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than A (H3N2) pneumonia.
登录
查看更多内容
影响因子：
5.4
作者：
Geiler, Janina;Michaelis, Martin;Cinatl, Jindrich, Jr.
通讯作者：
Cinatl, Jindrich, Jr.
影响因子：
5.4
作者：
Osterlund, Pamela;Pirhonen, Jaana;Julkunen, Ilkka
通讯作者：
Julkunen, Ilkka
影响因子：
6.4
作者：
Lee, Nelson;Chan, Paul K. S.;Hui, David. S. C.
通讯作者：
Hui, David. S. C.
影响因子：
5.1
作者：
To, Kelvin K. W.;Wong, Samson S. Y.;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
5.4
作者：
Monteiro, JM;Harvey, C;Trinchieri, G
通讯作者：
Trinchieri, G