Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains.
Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains.
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比较阿朴吗啡、安非他明和地佐西平对近交系和远交系小鼠品系前脉冲抑制的破坏。
DOI：
10.1016/s0014-2999(01)01115-3
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发表时间：
2001
影响因子：
5
通讯作者：
G. Carey
中科院分区：
文献类型：
--
作者：
G. Varty;N. Walters;M. Cohen;G. Carey
多巴胺激动剂阿波啡能强烈破坏大鼠声惊反应的脉冲前抑制，但已发表的研究尚未证明阿波啡能强烈破坏小鼠的脉冲前抑制。本研究的目的是建立最佳的预脉冲条件（通过操纵预脉冲强度和刺激间隔）和小鼠品系来测试阿波啡，以及干扰预脉冲抑制的药物安非他明和二唑西平（MK-801）。在CD-1、Swiss Webster （CFW）近交系和C57BL/6、129X1/SvJ、A/J近交系中检测了这些药物对惊跳反应和脉前抑制的影响。与基线惊吓和脉冲前抑制存在菌株差异，CD-1、CFW和C57BL/6菌株表现出高水平的惊吓和脉冲前抑制，129X1/SvJ菌株表现出低水平的惊吓和高水平的脉冲前抑制，而A/J菌株表现出低水平的惊吓和无脉冲前抑制。阿波啡破坏了CFW和C57BL/6菌株的脉冲前抑制作用，且仅在短的30 ms刺激间隔内才有明显的效果。安非他明破坏了CFW、C57BL/6和129X1/SvJ菌株的预脉冲抑制，二唑西平破坏了CD-1、CFW、C57BL/6和129X1/SvJ菌株的预脉冲抑制。安非他明和地佐西平的作用与刺激间期无关。这些研究表明，受惊反应和预脉冲抑制存在明显的品系差异，以及预脉冲抑制的药理学中断，并提示在小鼠中检测阿波啡的效果时，刺激间隔小于100 ms可能是最佳的。
The dopamine agonist apomorphine robustly disrupts prepulse inhibition of the acoustic startle response in the rat, yet published studies have not demonstrated a robust disruption of prepulse inhibition with apomorphine in the mouse. The aim of these studies was to establish the optimal prepulse conditions (using manipulations to prepulse intensity and inter-stimulus interval) and mouse strain(s) for testing apomorphine, and also the prepulse inhibition disrupting drugs amphetamine, and dizocilpine (MK-801). The effects of these drugs on startle response and prepulse inhibition were tested in outbred CD-1 and Swiss Webster (CFW) strains, and the inbred C57BL/6, 129X1/SvJ, and A/J strains. There were strain differences with baseline startle and prepulse inhibition in that the CD-1, CFW, and C57BL/6 strains exhibited high levels of startle and prepulse inhibition, the 129X1/SvJ strain exhibited low levels of startle but high levels of prepulse inhibition, while the A/J strain exhibited low startle and no prepulse inhibition. Apomorphine disrupted prepulse inhibition in the CFW and C57BL/6 strains and the effect was only evident when using a short 30 ms inter-stimulus interval. Amphetamine disrupted prepulse inhibition in the CFW, C57BL/6, and 129X1/SvJ strains, and dizocilpine disrupted prepulse inhibition in the CD-1, CFW, C57BL/6, and 129X1/SvJ strains. The effects of amphetamine and dizocilpine were independent of the inter-stimulus interval. These studies demonstrated clear strain differences in the startle response and prepulse inhibition, and the pharmacological disruptions of prepulse inhibition, and suggest that inter-stimulus intervals less than 100 ms may be optimal for detecting the effects of apomorphine in mice.
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小鼠前脉冲抑制的精神药理学。
DOI：
--
发表时间：
1996
期刊：
The Chinese journal of physiology
影响因子：
--
作者：
Dulawa,SC;Geyer,MA
通讯作者：
Geyer,MA
DOI：
--
发表时间：
1994-11
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
V. Bakshi;N. Swerdlow;M. Geyer
通讯作者：
V. Bakshi;N. Swerdlow;M. Geyer
影响因子：
--
作者：
D. Braff;C. Grillon;M. Geyer
通讯作者：
D. Braff;C. Grillon;M. Geyer
影响因子：
--
作者：
N. Swerdlow;D. Braff;N. Taaid;M. Geyer
通讯作者：
N. Swerdlow;D. Braff;N. Taaid;M. Geyer
思瑞康恢复苯环己哌啶治疗大鼠的感觉运动门控。
DOI：
--
发表时间：
1996
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Swerdlow,NR;Bakshi,V;Geyer,MA
通讯作者：
Geyer,MA