Bi-phase locking - a tool for probing non-linear interaction in the human brain.
Bi-phase locking - a tool for probing non-linear interaction in the human brain.
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DOI：
10.1016/j.neuroimage.2009.01.034
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发表时间：
2009-05-15
期刊：
影响因子：
5.7
通讯作者：
Sorensen LB
中科院分区：
文献类型：
--
作者：
Darvas F;Ojemann JG;Sorensen LB
我们提出了一种新的方法来检测皮层区域的电输出之间的频率-频率耦合，该方法由皮层脑电(ECoG)、脑电(EEG)和脑磁图(MEG)测量，即双相锁定值(BPLV)。我们的方法是众所周知的锁相值(PLV)的推广，并且对非线性相互作用特别敏感，即跨频率的二次相位耦合。由于其对非线性相互作用的敏感性，它对线性串扰引起的伪同步具有很强的鲁棒性，这在分析EEG/MEG记录的数据时是一个特别有用的特性。我们讨论了bPLV的统计性质，特别是在感兴趣的信号之间随机相位的假设下bPLV的分布。我们还比较了模拟脑电/脑磁图数据计算的大脑皮层相互作用的bPLV和PLV。这些数据被用逆解映射到大脑皮层。我们展示了我们的方法，从一个癫痫患者的运动皮质记录的事件相关的ECoG数据，他执行了一个提示的手指运动任务。我们发现在运动前区域，运动相关的α(12赫兹)和高γ(77赫兹)频段之间的bPLV显著增加，耦合到运动皮质89赫兹的高γ。
We present a novel method for detecting frequency-frequency coupling between the electrical output of cortical areas as measured by electrocorticography (ECoG), electroencephalography (EEG) and magnetoencephalography (MEG), the biphase-locking value (bPLV). Our method is an extension of the well known phase-locking value (PLV) and is specifically sensitive to non-linear interactions, i.e quadratic phase coupling across frequencies. Due to its sensitivity to non-linear interactions, it is robust to spurious synchronization arising from linear crosstalk, which is an especially useful property when analyzing data recorded by EEG/MEG. We discuss the statistical properties of the bPLV, specifically the distribution of the bPLV under assumption of random phases between the signals of interest. We also compare the bPLV to the PLV for cortical interactions that are computed for simulated EEG/MEG data. These data were mapped to the cortex using an inverse solution. We demonstrate our method for event related ECoG data recorded from the motor cortex of an epileptic patient, who performed a cued finger movement task. We find highly significant, movement related increase of the bPLV between the α (12 Hz) and high γ (77 Hz) band in a pre-motor area, coupling to high γ at 89 Hz in the motor cortex.
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影响因子：
3.7
作者：
Ahissar, E;Kleinfeld, D
通讯作者：
Kleinfeld, D
DOI：
10.1016/0013-4694(95)00230-8
发表时间：
1996-02-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Shils, JL;Litt, M;Stecker, MM
通讯作者：
Stecker, MM
影响因子：
8.6
作者：
Tass, P;Rosenblum, MG;Freund, HJ
通讯作者：
Freund, HJ
影响因子：
5.7
作者：
Darvas, F;Pantazis, D;Leahy, RM
通讯作者：
Leahy, RM
影响因子：
64.8
作者：
Gabbiani, F;Krapp, HG;Laurent, G
通讯作者：
Laurent, G