Biological influence of Hakai in cancer: a 10-year review.
Biological influence of Hakai in cancer: a 10-year review.
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DOI：
10.1007/s10555-012-9348-x
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发表时间：
2012-06
影响因子：
9.2
通讯作者：
Figueroa, Angelica
中科院分区：
文献类型：
--
作者：
Aparicio, Luis A.;Valladares, Manuel;Blanco, Moises;Alonso, Guillermo;Figueroa, Angelica
为了转移，癌细胞必须首先从原发肿瘤分离，迁移，侵入组织，并附着到第二个部位。Hakai被发现是一种E3泛素连接酶，介导E-钙粘蛋白的翻译后下调，E-钙粘蛋白是上皮细胞中粘附连接的主要成分，其特征在于是一种有效的肿瘤抑制剂，并在包括上皮-间充质转化在内的各种过程中受到调节。最近的数据为Hakai在肿瘤进展和其他疾病中的新生物学功能作用提供了证据。在这里，我们将回顾自10年前发现Hakai以来积累的知识及其对人类癌症疾病的影响。我们将强调不同的信号通路导致对Hakai的影响，并建议其作为癌症治疗靶点的潜在用途。
In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells that is characterized as a potent tumor suppressor and is modulated during various processes including epithelial–mesenchymal transition. Recent data have provided evidences for novel biological functional role of Hakai during tumor progression and other diseases. Here, we will review the knowledge that has been accumulated since Hakai discovery 10 years ago and its implication in human cancer disease. We will highlight the different signaling pathways leading to the influence on Hakai and suggest its potential usefulness as therapeutic target for cancer.
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影响因子：
64.5
作者：
Drees, F;Pokutta, S;Weis, WI
通讯作者：
Weis, WI
影响因子：
3.3
作者：
Figueroa, Angelica;Kotani, Hirokazu;Fujita, Yasuyuki
通讯作者：
Fujita, Yasuyuki
影响因子：
5.3
作者：
Chang, BY;Conroy, KB;Cartwright, CA
通讯作者：
Cartwright, CA
影响因子：
19
作者：
D'Souza-Schorey, C
通讯作者：
D'Souza-Schorey, C
影响因子：
8
作者：
Fan, SJ;Ma, YX;Rosen, EM
通讯作者：
Rosen, EM