CMV and Immunosenescence: from basics to clinics.

CMV and Immunosenescence: from basics to clinics.
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DOI:
10.1186/1742-4933-9-23
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发表时间:
2012-10-31
期刊:
Immunity & ageing : I & A
影响因子:
--
通讯作者:
Pawelec G
Pawelec G
中科院分区:
其他
文献类型:
--
作者:
Solana R;Tarazona R;Aiello AE;Akbar AN;Appay V;Beswick M;Bosch JA;Campos C;Cantisán S;Cicin-Sain L;Derhovanessian E;Ferrando-Martínez S;Frasca D;Fulöp T;Govind S;Grubeck-Loebenstein B;Hill A;Hurme M;Kern F;Larbi A;López-Botet M;Maier AB;McElhaney JE;Moss P;Naumova E;Nikolich-Zugich J;Pera A;Rector JL;Riddell N;Sanchez-Correa B;Sansoni P;Sauce D;van Lier R;Wang GC;Wills MR;Zieliński M;Pawelec G

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在疱疹病毒中,持续性巨细胞病毒(CMV)明显改变了感染者与未感染者外周免疫细胞的数量和比例。由于在大多数国家,CMV感染率随着年龄的增长而增加,因此有人认为它会驱动或至少加剧“免疫衰老”。这一争论仍然存在争议,并且是2012年3月15日至16日在西班牙科尔多瓦举行的第三届CMV和免疫衰老国际研讨会的主要主题。讨论集中在几个主要主题,包括CMV对适应性免疫和免疫衰老的影响,CMV特异性T细胞的表征,CMV感染和衰老对先天免疫的影响,最后,最重要的是,免疫衰老和CMV感染的临床意义。在此,我们总结了这次研讨会的主要发现。
Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
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