Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma.
Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma.
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DOI：
10.1155/2013/206525
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发表时间：
2013
影响因子：
--
通讯作者：
Gao Y
中科院分区：
文献类型：
--
作者：
Guo X;Sun T;Yang M;Li Z;Li Z;Gao Y
背景水通道蛋白（AQP）3和AQP 5参与多种肿瘤类型的肿瘤发生和肿瘤进展。瞄准目的探讨水通道蛋白3（AQP3）和水通道蛋白5（AQP5）在肝细胞癌（HCC）中的表达及其临床意义。方法.采用免疫组化法检测肝癌组织中AQP3和AQP5的表达。结果免疫组化结果显示，AQP 3和AQP 5蛋白在肝癌组织中的表达明显高于癌旁组织（P均< 0.001）。此外，AQP 3和AQP 5蛋白的联合表达与血清AFP（P = 0.008）、肿瘤分期（P = 0.006）和肿瘤分级（P = 0.006）显著相关。此外，高表达AQP3和AQP5蛋白的HCC患者的5年无病生存率和5年总生存率更差（P = 0.002和0.005，分别）。此外，考克斯比例风险模型显示，联合AQP 3和AQP 5蛋白表达是HCC 5年无病生存率（P = 0.009）和5年总生存率（P = 0.01）的独立不良预后因素。结论我们的数据首次表明，AQP3和AQP5蛋白的异常表达可能与HCC患者的肿瘤进展和预后密切相关。AQP3的过度表达和AQP5的上调可能是HCC的不利预后因素。
Background. Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. Aim. To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). Methods. Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 in HCC tissues. Results. Immunohistochemistry analysis showed the increased expression of AQP3 and AQP5 protein levels in HCC tissues compared with their adjacent nonneoplastic tissues (both P < 0.001). In addition, combined AQP3 and AQP5 protein expression was significantly associated with serum AFP (P = 0.008), tumor stage (P = 0.006), and tumor grade (P = 0.006). Moreover, HCC patients highly expressing both AQP3 and AQP5 proteins had worse 5-year disease-free survival and 5-year overall survival (P = 0.002 and 0.005, resp.). Furthermore, the Cox proportional hazards model showed that combined AQP3 and AQP5 protein expression was an independent poor prognostic factor for both 5-year disease-free survival (P = 0.009) and 5-year overall survival (P = 0.01) in HCC. Conclusion. Our data suggest for the first time that the aberrant expression of AQP3 and AQP5 proteins may be strongly related to tumor progression and prognosis in patients with HCC. The overexpression of AQP3 in combination with upregulation of AQP5 may be an unfavorable prognostic factor for HCC.
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影响因子：
2.3
作者：
Watanabe, Tomoko;Fujii, Takuto;Sakai, Hideki
通讯作者：
Sakai, Hideki
影响因子：
10.5
作者：
Verkman AS
通讯作者：
Verkman AS
影响因子：
3.8
作者：
Otto W;Rubenwolf PC;Burger M;Fritsche HM;Rößler W;May M;Hartmann A;Hofstädter F;Wieland WF;Denzinger S
通讯作者：
Denzinger S
影响因子：
4.7
作者：
Yang, JH;Shi, YF;Deng, L
通讯作者：
Deng, L
影响因子：
6
作者：
Kang, Sung Koo;Chae, Young Kwang;Moon, Chulso
通讯作者：
Moon, Chulso