RADx-UP Testing Core: Access to COVID-19 Diagnostics in Community-Engaged Research with Underserved Populations.
RADx-UP Testing Core: Access to COVID-19 Diagnostics in Community-Engaged Research with Underserved Populations.
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DOI：
10.1128/jcm.00367-23
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发表时间：
2023-08-23
影响因子：
9.4
通讯作者：
Petti, Cathy A.
中科院分区：
文献类型：
--
作者：
Narayanasamy, Shanti;Veldman, Timothy H.;Lee, Mark J.;Glover II, William A.;Tillekeratne, L. Gayani;Neighbors, Coralei E.;Harper, Barrie;Raghavan, Vidya;Kennedy, Scott W.;Carper, Miranda;Denny, Thomas;Tsalik, Ephraim L.;Reller, Megan E.;Kibbe, Warren A.;Corbie, Giselle;Cohen-Wolkowiez, Michael;Woods, Christopher W.;Petti, Cathy A.
对COVID-19大流行的研究表明，在服务不足的人群中，COVID-19感染和死亡的负担不成比例，这些社区的SARS-CoV-2检测率较低。制定了一项具有里程碑意义的美国国立卫生研究院（NIH）资助倡议，即快速加速服务不足人群诊断（RADx-UP）计划，以解决在了解在服务不足人群中采用COVID-19检测方面的研究差距。这个项目是NIH历史上在健康差异和社区参与研究方面最大的一笔投资。RADx-UP检测核心（TC）为社区调查人员提供有关COVID-19诊断的基本科学专业知识和指导。本评论描述了技术委员会头两年的经验，强调了在大流行期间安全有效地为社区发起的研究部署大规模诊断方法所面临的挑战和获得的见解。RADx-UP的成功表明，在大流行期间，通过集中检测协调中心提供的工具、资源和多学科专业知识，可以完成以社区为基础的研究，以增加服务不足人群获得和接受检测的机会。我们开发了自适应工具来支持这些不同研究的个人测试策略和框架，并确保对测试策略和研究数据的使用进行持续监测。在快速发展的巨大不确定性环境中，TC提供了必要的实时技术专长，以支持安全、有效和自适应的测试。吸取的经验教训不仅限于这次大流行，而且可以作为快速部署检测的框架，以应对未来的危机，特别是在人口受到不公平影响的情况下。
Research on the COVID-19 pandemic revealed a disproportionate burden of COVID-19 infection and death among underserved populations and exposed low rates of SARS-CoV-2 testing in these communities. A landmark National Institutes of Health (NIH) funding initiative, the Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program, was developed to address the research gap in understanding the adoption of COVID-19 testing in underserved populations. This program is the single largest investment in health disparities and community-engaged research in the history of the NIH. The RADx-UP Testing Core (TC) provides community-based investigators with essential scientific expertise and guidance on COVID-19 diagnostics. This commentary describes the first 2 years of the TC’s experience, highlighting the challenges faced and insights gained to safely and effectively deploy large-scale diagnostics for community-initiated research in underserved populations during a pandemic. The success of RADx-UP shows that community-based research to increase access and uptake of testing among underserved populations can be accomplished during a pandemic with tools, resources, and multidisciplinary expertise provided by a centralized testing-specific coordinating center. We developed adaptive tools to support individual testing strategies and frameworks for these diverse studies and ensured continuous monitoring of testing strategies and use of study data. In a rapidly evolving setting of tremendous uncertainty, the TC provided essential and real-time technical expertise to support safe, effective, and adaptive testing. The lessons learned go beyond this pandemic and can serve as a framework for rapid deployment of testing in response to future crises, especially when populations are affected inequitably.
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影响因子：
2.1
作者：
Landman JM;Steger-May K;Joynt Maddox KE;Hammond G;Gupta A;Rauseo AM;Zhao M;Foraker RE
通讯作者：
Foraker RE
DOI：
10.1073/pnas.2020685118
发表时间：
2021-02-23
影响因子：
11.1
作者：
Perry BL;Aronson B;Pescosolido BA
通讯作者：
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影响因子：
4.5
作者：
Embrett, Mark;Sim, S. Meaghan;Caldwell, Hilary A. T.;Boulos, Leah;Yu, Ziwa;Agarwal, Gina;Cooper, Rhiannon;Gallant, Allyson J. A. J.;Bielska, Iwona A.;Chishtie, Jawad;Stone, Kathryn;Curran, Janet;Tricco, Andrea
通讯作者：
Tricco, Andrea
DOI：
10.1097/phh.0000000000001510
发表时间：
2022-07-01
影响因子：
3.3
作者：
Pond, Emily N.;Rutkow, Lainie;Blauer, Beth;Alonso, Angel Aliseda;de Lis, Sara Bertran;Nuzzo, Jennifer B.
通讯作者：
Nuzzo, Jennifer B.
影响因子：
4.8
作者：
Brandt K;Goel V;Keeler C;Bell GJ;Aiello AE;Corbie-Smith G;Wilson E;Fleischauer A;Emch M;Boyce RM
通讯作者：
Boyce RM