A Role for Insulin in Diabetic Neuropathy.
A Role for Insulin in Diabetic Neuropathy.
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DOI：
10.3389/fnins.2016.00581
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发表时间：
2016
影响因子：
4.3
通讯作者：
Wright DE
中科院分区：
文献类型：
--
作者：
Grote CW;Wright DE
周围神经系统是糖尿病严重影响的几个器官系统之一。长期以来的观点是，胰岛素在中枢和外周神经系统中调节神经元功能方面没有主要作用，现在正受到挑战。在胰岛素缺乏或胰岛素过量的情况下，合理的建议是胰岛素失调可以导致感觉神经元的神经病理性变化。这一点尤其重要，因为与前驱糖尿病、1型和2型糖尿病相关的感觉神经损伤非常普遍。在这里，我们讨论了目前的实验文献相关的胰岛素作为一种潜在的神经营养因子在周围神经功能，以及胰岛素缺乏在糖尿病神经病变中发挥作用的可能性。此外，我们还讨论了周围神经系统中的感觉神经元如何与其他胰岛素敏感组织一样对胰岛素作出反应。此外，现在的研究表明，感觉神经元也可以像其他组织一样变得胰岛素抵抗。总的来说，新兴的研究表明，胰岛素信号通路是感觉神经调制的积极贡献者，这篇综述强调了这种新的活动，并应提供新的见解胰岛素在外周和中枢神经系统疾病中的作用。
The peripheral nervous system is one of several organ systems that are profoundly affected in diabetes. The longstanding view is that insulin does not have a major role in modulating neuronal function in both central and peripheral nervous systems is now being challenged. In the setting of insulin deficiency or excess insulin, it is logical to propose that insulin dysregulation can contribute to neuropathic changes in sensory neurons. This is particularly important as sensory nerve damage associated with prediabetes, type 1 and type 2 diabetes is so prevalent. Here, we discuss the current experimental literature related to insulin's role as a potential neurotrophic factor in peripheral nerve function, as well as the possibility that insulin deficiency plays a role in diabetic neuropathy. In addition, we discuss how sensory neurons in the peripheral nervous system respond to insulin similar to other insulin-sensitive tissues. Moreover, studies now suggest that sensory neurons can also become insulin resistant like other tissues. Collectively, emerging studies are revealing that insulin signaling pathways are active contributors to sensory nerve modulation, and this review highlights this novel activity and should provide new insight into insulin's role in both peripheral and central nervous system diseases.
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影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
影响因子：
7.1
作者：
Grote CW;Groover AL;Ryals JM;Geiger PC;Feldman EL;Wright DE
通讯作者：
Wright DE
影响因子：
3.3
作者：
Choeiri, C;Staines, W;Messier, C
通讯作者：
Messier, C
影响因子：
7.7
作者：
Brussee, V;Cunningham, FA;Zochodne, DW
通讯作者：
Zochodne, DW
影响因子：
7.7
作者：
GREENE, DA;WINEGRAD, AI
通讯作者：
WINEGRAD, AI