Dioxin induction of transgenerational inheritance of disease in zebrafish.
Dioxin induction of transgenerational inheritance of disease in zebrafish.
复制标题
斑马鱼中疾病的跨代遗传的二恶英诱导。
DOI：
10.1016/j.mce.2014.08.011
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发表时间：
2014-12
影响因子：
4.1
通讯作者：
Heideman W
中科院分区：
文献类型：
--
作者：
Baker TR;King-Heiden TC;Peterson RE;Heideman W
二恶英（2,3,7,8-四氯二苯并-对二恶英；TCDD）是一种芳烃受体（AHR）激动剂，内分泌干扰物，是一种强有力的全球性污染物。TCDD暴露与几乎所有器官系统的疾病有关，其毒性在脊椎动物中高度保守。虽然二恶英暴露的急性发育影响已被广泛研究，但早期亚致死暴露对成年期或后代产生毒性的能力尚不清楚。由于影响的时间范围，这类问题很难研究。对于人类受试者来说，这样的研究可能超过一生的时间。我们选择斑马鱼（Danio rerio）作为模型，因为它们是脊椎动物，世代时间短，遗传背景一致。斑马鱼有非常适度的住房需求，以最少的时间和费用促进单代和多代研究。我们使用这个模型来确定TCDD对骨骼发育、性别比例和男性介导的生殖能力下降的跨代影响。在这里，我们将这些发现与在实验室啮齿动物物种中描述的跨代效应进行比较。我们提出，斑马鱼是一个具有成本效益的模型系统，用于评估有毒化学物质的跨代效应及其在成人疾病的胎儿基础中的作用。
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) is an aryl hydrocarbon receptor (AHR) agonist, an endocrine disruptor, and a potent global pollutant. TCDD exposure is associated with diseases of almost every organ system, and its toxicity is highly conserved across vertebrates. While the acute developmental effects of dioxin exposure have been extensively studied, the ability of early sublethal exposure to produce toxicity in adulthood or subsequent generations is poorly understood. This type of question is difficult to study because of the time frame of the effects. With human subjects, such a study could span more than a lifetime. We have chosen zebrafish (Danio rerio) as a model because they are vertebrates with short generation times and consistent genetic backgrounds. Zebrafish have very modest housing needs, facilitating single and multigenerational studies with minimal time and expense. We have used this model to identify transgenerational effects of TCDD on skeletal development, sex ratio, and male-mediated decreases in reproductive capacity. Here we compare these findings with transgenerational effects described in laboratory rodent species. We propose that the zebrafish is a cost-effective model system for evaluating the transgenerational effects of toxic chemicals and their role in the fetal basis of adult disease.
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DOI：
10.1073/pnas.0610410104
发表时间：
2007-04-03
影响因子：
11.1
作者：
Crews, David;Gore, Andrea C.;Skinner, Michael K.
通讯作者：
Skinner, Michael K.
影响因子：
4.6
作者：
Grandjean, Valerie;Gounon, Pierre;Rassoulzadegan, Minoo
通讯作者：
Rassoulzadegan, Minoo
影响因子：
15.8
作者：
Baccarelli A;Giacomini SM;Corbetta C;Landi MT;Bonzini M;Consonni D;Grillo P;Patterson DG;Pesatori AC;Bertazzi PA
通讯作者：
Bertazzi PA
影响因子：
4.3
作者：
Fang X;Thornton C;Scheffler BE;Willett KL
通讯作者：
Willett KL
苯并暴露后，对斑马鱼胚胎和幼虫中特定启动子DNA甲基化的影响。
DOI：
10.1016/j.cbpc.2014.02.005
发表时间：
2014-06
影响因子：
3.9
作者：
Corrales, J.;Fang, X.;Thornton, C.;Mei, W.;Barbazuk, W. B.;Duke, M.;Scheffler, B. E.;Willett, K. L.
通讯作者：
Willett, K. L.