Heritability of Psychological Traits and Developmental Milestones in Infancy: A Systematic Review and Meta-analysis.
Heritability of Psychological Traits and Developmental Milestones in Infancy: A Systematic Review and Meta-analysis.
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DOI：
10.1001/jamanetworkopen.2022.27887
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发表时间：
2022-08-01
影响因子：
13.8
通讯作者：
中科院分区：
文献类型：
--
作者：
这篇系统的综述和荟萃分析调查了遗传和共享和非共享环境因素与婴儿发育里程碑的相关性。对于婴儿期的心理特征和发展里程碑，总体的遗传、共享和非共享环境估计是什么？在这项涉及全球近80个 000双胞胎的139项婴儿双胞胎研究的系统综述和荟萃分析中，发现了对婴儿时期一系列重要心理特征和发育里程碑的中等到高度的遗传以及共享和非共享环境的估计。这些结果提供了对基因和环境评估婴儿功能关键领域结果的程度的洞察，并提出了高度可遗传的特征，这些特征可能特别适合于基因发现。虽然婴儿期是出生后生长和发育最快的时期，但与婴儿特征变异相关的因素尚不清楚。综合大型双胞胎研究文献，将婴儿期心理特征和发育里程碑的表型差异划分为遗传力和共享和非共享环境的估计。检索PubMed、SqucINFO和所收录出版物的参考文献，截止到2021年2月11日。使用经典的双胞胎设计研究从出生到2岁的心理特征和发育里程碑的同行评议出版物被包括在内。根据系统审查和荟萃分析的首选报告项目提取数据，并使用《国际功能、残疾和健康分类：儿童和青年版》进行分类。数据汇集在三水平随机效应模型中，包括结果测量的队列内方差和队列间方差。对2021年3月至2021年9月的数据进行了分析。主要结果是单合子和异卵双胞胎相关。这些数据被用来计算遗传、共享和非共享环境估计。在系统检索的139篇文章中，有79对 044双胞胎(31对 053单合子和47对 991双合子)、52个独立样本和21个国家的数据。对106种出版物的心理特征和发展里程碑进行了Meta分析，这些出版物被分成10个类别：功能、残疾和健康。有8个类别的遗传估计值为中等到高，其中最高的是精神运动功能(合并H2，0.59；95%CI，0.25-0.79；P <； .001)。有几类特征有相当大的共同环境估计，最高的是语言的心理功能(集合c2，0.59；95%CI，0.24-0.86；P = .001)。所有被考察的特征类别都有中等或较高的非共享环境估计，其中最高的是情感功能(合并e2，0.42；95%CI，0.33-0.50；P <； .001)和家庭关系(合并e2，0.42；95%CI，0.30-0.55；P <； .001)。这些发现可能是一个重要的信息来源，以指导未来的基因发现研究，公众对天生和养育的看法，以及临床洞察家庭历史和环境可能在多大程度上评估心理特征和发育里程碑中的婴儿功能、残疾和健康的主要领域。
This systematic review and meta-analysis investigates the correlation of genetic and shared and nonshared environment factors with infant developmental milestones. What are the overall genetic and shared and nonshared environment estimates for psychological traits and developmental milestones in infancy? In this systematic review and meta-analysis of 139 infant twin studies involving almost 80 000 twins globally, moderate to high genetic and shared and nonshared environment estimates were found across a range of important psychological traits and developmental milestones in infancy. These results offer insight into the degree to which genes and environments estimate outcomes in key domains of infant functioning and suggest highly heritable traits that may be particularly suitable candidates for gene discovery. Although infancy is the most rapid period of postnatal growth and development, factors associated with variation in infant traits are not well understood. To synthesize the large twin study literature partitioning phenotypic variance in psychological traits and developmental milestones in infancy into estimates of heritability and shared and nonshared environment. PubMed, PsycINFO, and references of included publications were searched up to February 11, 2021. Peer-reviewed publications using the classical twin design to study psychological traits and developmental milestones from birth to 2 years old were included. Data were extracted in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and categorized using the International Classification of Functioning, Disability and Health: Children and Youth Version. Data were pooled in 3-level random effects models, incorporating within-cohort variance in outcome measurement and between-cohort variance. Data were analyzed from March 2021 through September 2021. The primary outcomes were monozygotic and dizygotic twin correlations. These were used to calculate genetic and shared and nonshared environment estimates. Among 139 publications that were systematically retrieved, data were available on 79 044 twin pairs (31 053 monozygotic and 47 991 dizygotic pairs), 52 independent samples, and 21 countries. Meta-analyses were conducted on psychological traits and developmental milestones from 106 publications organized into 10 categories of functioning, disability, and health. Moderate to high genetic estimates for 8 categories were found, the highest of which was psychomotor functions (pooled h2, 0.59; 95% CI, 0.25-0.79; P < .001). Several categories of traits had substantial shared environment estimates, the highest being mental functions of language (pooled c2, 0.59; 95% CI, 0.24-0.86; P = .001). All examined categories of traits had moderate or high nonshared environment estimates, the highest of which were emotional functions (pooled e2, 0.42; 95% CI, 0.33-0.50; P < .001) and family relationships (pooled e2, 0.42; 95% CI, 0.30-0.55; P < .001). These findings may be an important source of information to guide future gene discovery research, public perspectives on nature and nurture, and clinical insights into the degree to which family history and environments may estimate major domains of infant functioning, disability, and health in psychological traits and developmental milestones.
影响因子：
3.2
作者：
Custodio RJ;Junior CE;Milani SL;Simões AL;de Castro M;Moreira AC
通讯作者：
Moreira AC
影响因子：
3.7
作者：
Rhee SH;Corley RP;Friedman NP;Hewitt JK;Hink LK;Johnson DP;Robinson J;Smith AK;Young SE
通讯作者：
Young SE