The emergence of the cortisol circadian rhythm in monozygotic and dizygotic twin infants: the twin-pair synchrony.
The emergence of the cortisol circadian rhythm in monozygotic and dizygotic twin infants: the twin-pair synchrony.
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DOI：
10.1111/j.1365-2265.2006.02706.x
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发表时间：
2007-02
影响因子：
3.2
通讯作者：
Moreira AC
中科院分区：
文献类型：
--
作者：
Custodio RJ;Junior CE;Milani SL;Simões AL;de Castro M;Moreira AC
遗传因素对婴儿皮质醇昼夜节律个体发育的影响研究较少。本研究旨在探讨双生子对唾液皮质醇节律出现年龄的影响及其遗传力。对34例婴儿（10对同卵双生（MZ）和7对异卵双生（DZ））在出生后2、4、8、12、16、20和24周的早晨和夜间采集唾液样本进行纵向研究。用放射免疫法测定唾液皮质醇。通过至少13个短串联重复序列多态性的DNA分析来验证Z型。计算皮质醇昼夜节律出现的差异、双生子内的组内相关系数和遗传力指数（h2）。MZ和DZ出现唾液皮质醇昼夜节律的平均（± SEM）年龄相似（7.8 ± 1.0 vs 7.4 ± 1.3周）。7对显示皮质醇节律的出现是一致的。10对唾液昼夜节律不一致，其中MZ组和DZ组唾液昼夜节律出现的对内差异相似。组内相关系数rMZ = 0.60，P = 0.02; rDZ = 0.65，P = 0.03。遗传力指数（h2）为0.21（ns）。MZ和DZ双胞胎婴儿的唾液昼夜节律出现在相同的生后年龄。虽然可能涉及几个生理方面，遗传力指数，在本研究中获得的，表明少遗传比环境的影响的发病年龄的皮质醇昼夜节律。我们的数据还表明，每对双胞胎都表现出同步性，因为他们可能在出生前和出生后共享环境同步器。
Studies on the influence of genetic factors on the ontogeny of cortisol circadian rhythm in infants are lacking. This study evaluated the influence of twinning and the heritability on the age of emergence of salivary cortisol rhythm. A longitudinal study was performed using salivary samples obtained during morning and night, at 2, 4, 8, 12, 16, 20 and 24 weeks of postnatal life in 34 infants, 10 monozygotic (MZ) and 7 dizygotic (DZ) twin pairs. Salivary cortisol was determined by radioimmunoassay (RIA). Zigosity was verified by DNA analysis of at least 13 short tandem repeat polymorphisms. Difference of the emergence of cortisol circadian rhythm, within each twin pair, the intraclass correlation coefficient and the heritability index (h2) were calculated. The mean (± SEM) age of emergence of salivary cortisol circadian rhythm was similar in MZ and DZ (7·8 ± 1·0 vs 7·4 ± 1·3 weeks). Seven pairs showed coincidence of the emergence of cortisol rhythm. Ten pairs were not coincident; among them the within-pair difference of emergence of salivary circadian rhythm was similar in both MZ and DZ groups. The intraclass correlation coefficients were rMZ = 0·60, P = 0·02; and rDZ = 0·65, P = 0·03, respectively. The heritability index (h2) was 0·21 (ns). Salivary circadian rhythm appeared at the same postnatal age in MZ and DZ twin infants. Although several physiological aspects might be involved, the heritability index, obtained in the present study, suggests less genetic than environmental impact on the age of the onset of the cortisol circadian rhythm. Our data also indicated that each twin-pair show synchrony because they probably shared prenatal and postnatal environmental synchronizers.
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影响因子：
3.2
作者：
Antonini, SRR;Jorge, SM;Moreira, AC
通讯作者：
Moreira, AC
影响因子：
3.7
作者：
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5.6
作者：
McGraw, K;Hoffmann, R;Herman, JH
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作者：
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通讯作者：
BISHOP, DT
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作者：
Pol, HEH;Posthuma, D;Boomsma, DI
通讯作者：
Boomsma, DI