Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer.
Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer.
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则气汤方通过 STAT3/S100A9/Bcl-2/Caspase-3 信号诱导粒细胞髓系抑制细胞凋亡，延长原位肺癌小鼠的生存期
DOI：
10.1155/2021/8856326
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发表时间：
2021
影响因子：
4.6
通讯作者：
Zou CP
中科院分区：
文献类型：
--
作者：
Xu ZH;Zhu YZ;Su L;Tang XY;Yao C;Jiao XN;Hou YF;Chen X;Wei LY;Wang WT;Wang J;Gong CY;Zhu XD;Zhang F;Zhu SG;Zou CP
非小细胞肺癌（NSCLC）是世界上发病率和死亡率最高的恶性肿瘤。在我们之前的研究中，我们发现一个经典的传统中药（TCM）配方泽芪汤（ZQT），这已经被用于治疗呼吸系统疾病的数千年，可以直接抑制人NSCLC细胞通过p53信号通路的生长。本研究探讨了ZQT的免疫调节功能。我们发现ZQT通过调节肿瘤微环境（TME）显着延长原位肺癌模型小鼠的生存期。ZQT通过STAT 3/S100 A9/Bcl-2/caspase-3信号通路诱导MDSC（尤其是G-MDSC）凋亡，从而显著减少MDSC的数量，抑制其免疫抑制活性。当G-MDSCs被耗尽时，ZQT对荷瘤小鼠的存活促进作用及其对肺发光信号的抑制作用消失。这是第一项阐明ZQT在NSCLC中的免疫调节作用及其潜在分子机制的研究。
Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.
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影响因子：
10.1
作者：
Gabrilovich DI
通讯作者：
Gabrilovich DI
影响因子：
17.1
作者：
Hu K;Miao L;Goodwin TJ;Li J;Liu Q;Huang L
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影响因子：
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Wu Z;Zhu Q;Yin Y;Kang D;Cao R;Tian Q;Zhang Y;Lu S;Liu P
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Liu P
影响因子：
4.6
作者：
Wan Liang-Qin;Tan Yan;Hua Qian
通讯作者：
Hua Qian
中药泽气汤方通过p53通路抑制非小细胞肺癌细胞生长
影响因子：
5.4
作者：
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通讯作者：
Zou, Chunpu