Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology.
Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology.
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DOI：
10.1016/j.bpc.2020.106507
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发表时间：
2021-02
影响因子：
3.8
通讯作者：
Ramamoorthy A
中科院分区：
文献类型：
--
作者：
Ivanova MI;Lin Y;Lee YH;Zheng J;Ramamoorthy A
蛋白质异常聚集成丝状聚集体通常与许多疾病有关，如阿尔茨海默病、帕金森病和2型糖尿病。这些丝状聚集体，也被称为淀粉样蛋白，可以将其异常结构传播到相同的前体分子（播种）或其他蛋白质单体（交叉播种）。交叉播种与异常蛋白质聚集有关，并已发现可促进生理性淀粉样蛋白的形成。它已成为一个令人兴奋的研究领域，发表了大量报告。在这篇综述文章中，我们重点介绍了一些最常见的淀粉样蛋白交叉播种的生物物理过程。在这里，我们将讨论与淀粉样蛋白- β、人胰岛淀粉样蛋白多肽（hIAPP，或也称为amylin）和α -突触核蛋白的交叉种子聚合有关的相关文献。本文还简要讨论了细菌curli蛋白与PAP248-286交叉播种后SEVI（精液源性病毒感染增强子）淀粉样蛋白的形成。
Abnormal aggregation of proteins into filamentous aggregates commonly associates with many diseases, such as Alzheimer’s disease, Parkinson’s disease and type-2 diabetes. These filamentous aggregates, also known as amyloids, can propagate their abnormal structures to either the same precursor molecules (seeding) or other protein monomers (cross-seeding). Cross-seeding has been implicated in the abnormal protein aggregation and has been found to facilitate the formation of physiological amyloids. It has risen to be an exciting area of research with a high volume of published reports. In this review article, we focus on the biophysical processes underlying the cross-seeding for some of the most commonly studied amyloid proteins. Here we will discuss the relevant literature related to cross-seeded polymerization of amyloid-beta, human islet amyloid polypeptide (hIAPP, or also known as amylin) and alpha-synuclein. SEVI (semen-derived enhancer of viral infection) amyloid formation by the cross-seeding between the bacterial curli protein and PAP248–286 is also briefly discussed.
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影响因子：
8.6
作者：
Appel-Cresswell, Silke;Vilarino-Guell, Carles;Farrer, Matthew J.
通讯作者：
Farrer, Matthew J.
α-突触核蛋白淀粉样蛋白劫持了prion蛋白以获得细胞的进入，促进细胞到细胞扩散并阻止prion复制。
影响因子：
4.6
作者：
Aulić S;Masperone L;Narkiewicz J;Isopi E;Bistaffa E;Ambrosetti E;Pastore B;De Cecco E;Scaini D;Zago P;Moda F;Tagliavini F;Legname G
通讯作者：
Legname G
使用分子动力学模拟在原子分辨率下的Amylin-Aβ低聚物：2型糖尿病与阿尔茨海默氏病之间的联系。
DOI：
10.1039/c5cp03338a
发表时间：
2016-01-28
期刊：
Physical chemistry chemical physics : PCCP
影响因子：
--
作者：
Baram M;Atsmon-Raz Y;Ma B;Nussinov R;Miller Y
通讯作者：
Miller Y
影响因子：
10.6
作者：
Castillo-Carranza DL;Guerrero-Muñoz MJ;Sengupta U;Gerson JE;Kayed R
通讯作者：
Kayed R
影响因子：
3
作者：
Chanson, Jean-Baptiste;Echaniz-Laguna, Andoni;Kiesmann, Michele
通讯作者：
Kiesmann, Michele