Predicting conversion to dementia of the Alzheimer's type in a healthy control sample: the power of errors in Stroop color naming.

Predicting conversion to dementia of the Alzheimer's type in a healthy control sample: the power of errors in Stroop color naming.
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DOI:
10.1037/a0017474
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发表时间:
2010-03
影响因子:
3.7
通讯作者:
Morris, John C.
Morris, John C.
中科院分区:
心理学2区
文献类型:
--
作者:
Balota, David A.;Tse, Chi-Shing;Hutchison, Keith A.;Spieler, Daniel H.;Duchek, Janet M.;Morris, John C.

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本研究调查了老年人在时间A的认知功能预测在时间B转化为阿尔茨海默型痴呆(DAT)。1992年至1994年,47名健康个体最初接受了逐个试验的计算机化Stroop任务测试,沿着一系列利用常识、陈述性记忆、视觉空间处理和处理速度的心理测量指标。这些人中有12人随后发展DAT。颜色不一致试验的错误(沿着与一致和不一致试验之间的差异),以及反应时间分布的变化是转换为DAT的最强预测因子,与最近关于这些措施的敏感性的争论一致。值得注意的是,在心理测量的措施,有很少的证据表明,在陈述性记忆之间的转换器和nonconverters的差异,但有一些证据的变化,在视觉空间处理。讨论的重点是越来越多的证据表明,注意力控制机制的作用,从健康的认知老化的过渡到DAT的早期标志。
The present study investigates which cognitive functions in older adults at time A are predictive of conversion to dementia of the Alzheimer type (DAT) at time B. Forty-seven healthy individuals were initially tested in 1992–1994 on a trial-by-trial computerized Stroop task along with a battery of psychometric measures that tap general knowledge, declarative memory, visual spatial processing, and processing speed. Twelve of these individuals subsequently developed DAT. The errors on the color incongruent trials (along with the difference between congruent and incongruent trials), and changes in the reaction time distributions were the strongest predictors of conversion to DAT, consistent with recent arguments regarding the sensitivity of these measures. Notably in the psychometric measures, there was little evidence of a difference in declarative memory between converters and nonconverters, but there was some evidence of changes in visual-spatial processing. Discussion focuses on the accumulating evidence suggesting a role of attentional control mechanisms as an early marker for the transition from healthy cognitive aging to DAT.
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