Exposure of mice to benzo(a)pyrene impairs endometrial receptivity and reduces the number of implantation sites during early pregnancy.
Exposure of mice to benzo(a)pyrene impairs endometrial receptivity and reduces the number of implantation sites during early pregnancy.
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小鼠暴露于苯并（a）芘会损害子宫内膜容受性并减少妊娠早期着床部位的数量。
DOI：
10.1016/j.fct.2014.04.021
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发表时间：
2014-07
影响因子：
4.3
通讯作者：
Junlin He
中科院分区：
文献类型：
--
作者：
Rufei Gao;Yiwen Qiu;Yingxiong Wang;Junlin He
苯并（a）芘（BaP）是一种普遍存在的环境污染物。研究表明，它是一种内分泌干扰化学品，可对女性生殖系统造成不良影响。然而，苯并（a）芘对早期妊娠的影响尚未有报道。我们研究了BaP对子宫内膜容受性和胚胎着床的影响。从妊娠第1天（D1）至第5天（D5），对妊娠小鼠给予0.2、2和20 mg/kg/天的BaP。BaP暴露可使子宫内膜形态学改变，着床点数目减少（p0.2= 0.006，p2 = 0.167，p20 = 0.003）。苯并（a）芘处理组血浆雌二醇（P< 0.001）和孕酮-4（P< 0.001，P <0.001，P <20 = 0.032）水平升高。雌激素受体α表达上调（p0.2= 0.002，p2 = 0.131，p20 = 0.024），孕激素受体表达下调（p0.2<0.001，p2 = 0.064，p20 = 0.021）。BaP可改变感受性相关基因HoxA 10（p0.2<0.001，p2 = 0.135，p20 < 0.001）和E-cadherin（p0.2= 0.002，p2 = 0.624，p20 = 0.137）的表达水平。提示BaP可破坏雌、孕激素平衡，影响雌、孕激素受体及其下游相关基因的表达，导致子宫内膜容受性改变，使着床点减少。
Benzo(a)pyrene (BaP) is a ubiquitous environmental pollutant. Studies have demonstrated it to be an endocrine-disrupting chemical that can cause adverse effects on the female reproductive system. However, the effect of BaP on early pregnancy has not been reported. We investigated the effect of BaP on endometrial receptivity and embryo implantation. Pregnant mice were dosed with BaP at 0.2, 2 and 20 mg/kg/day from day 1 (D1) to day 5 (D5) of gestation. Exposure to BaP impaired the morphology of the endometrium and decreased the number of implantation sites (p0.2= 0.006,p2= 0.167,p20= 0.003). Levels of estrodiol (p< 0.001, for three treatment group compare with control group) and progesterone-4 in plasma were elevated in BaP-treatment groups (p0.2< 0.001,p2< 0.001,p20= 0.032). Expression of estrogen receptor-α was up-regulated (p0.2= 0.002,p2= 0.131,p20= 0.024) whereas expression of the progesterone receptor was down-regulated (p0.2< 0.001,p2= 0.064,p20= 0.021). Levels of receptivity-related genes HoxA10 (p0.2< 0.001,p2= 0.135,p20< 0.001) and E-cadherin (p0.2= 0.002,p2= 0.624,p20= 0.137) were changed by BaP. These results revealed that BaP can disrupt the balance of estrogen and progesterone, influence expression of their receptors and downstream related genes, lead to changes in endometrium receptivity, and reduce of the number of implantation sites.
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影响因子：
3.7
作者：
Sun S;Chen G;Xu M;Qiao Y;Zheng S
通讯作者：
Zheng S
DOI：
10.1093/toxsci/70.2.193
发表时间：
2002-12
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
J. Vondráček;A. Kozubík;M. Machala
通讯作者：
J. Vondráček;A. Kozubík;M. Machala
影响因子：
4.6
作者：
G. Benson;H. Lim;B. Paria;I. Satokata;S. Dey;R. Maas
通讯作者：
G. Benson;H. Lim;B. Paria;I. Satokata;S. Dey;R. Maas
影响因子：
6.3
作者：
Awasthi, S.;Blesson, C. S.;Dwivedi, A.
通讯作者：
Dwivedi, A.
影响因子：
6.1
作者：
MARTEL, D;MONIER, MN;PSYCHOYOS, A
通讯作者：
PSYCHOYOS, A