Qualitative and quantitative assessment of adenosine triphosphate stress whole-heart dynamic myocardial perfusion imaging using 256-slice computed tomography.
Qualitative and quantitative assessment of adenosine triphosphate stress whole-heart dynamic myocardial perfusion imaging using 256-slice computed tomography.
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使用256片计算机断层扫描术的定性和定量评估三磷酸腺苷应力全心肌灌注成像。
DOI：
10.1371/journal.pone.0083950
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mochizuki T
中科院分区：
文献类型：
--
作者：
Kurata A;Kawaguchi N;Kido T;Inoue K;Suzuki J;Ogimoto A;Funada J;Higaki J;Miyagawa M;Vembar M;Mochizuki T
本研究的目的是利用应力动态全心计算机断层扫描灌注（CTP）成像256层CT定性低灌注区（HPA）跨壁范围与CTP衍生心肌血流量（MBF）的相关性，以评估冠状动脉狭窄的严重程度。11例患者行三磷酸腺苷（0.16 mg/kg/min, 5 min）应激动态CTP 256层CT（覆盖：8 cm， 0.27 s/旋转），9例患者行冠状动脉造影（CAG）。通过前瞻性ECG门控（有效辐射剂量：10.4 mSv）获得应激动态CTP（收缩期连续30次心跳的全心数据集，无空间和时间间隙）。hpa的程度用3分评分目视分级（正常、心内膜下、经壁）。反褶积法测定MBF （ml/100g/min）。根据HPA和CAG结果评估MBF的差异（平均值±标准误差）。在27个区域（9例患者3个主要冠状动脉区域），观察到11个冠状动脉狭窄（直径缩小50%）。在353个心肌节段中，HPA与MBF显著相关（P < 0.05，正常295±94，心内膜下186±67，经壁80±53）。冠脉范围分析显示冠脉狭窄严重程度与MBF有显著相关性（P < 0.05，无显著性狭窄[< 50%],284±97，中度狭窄[50-70%]，184±74，重度狭窄[bb0 70%]， 119±69）。256层CT应力全心动态CTP成像定性HPA跨壁范围与定量CTP衍生的MBF具有良好的相关性，有助于评估冠状动脉疾病的血流动力学意义。
The aim of this study was to investigate the correlation of the qualitative transmural extent of hypoperfusion areas (HPA) using stress dynamic whole-heart computed tomography perfusion (CTP) imaging by 256-slice CT with CTP-derived myocardial blood flow (MBF) for the estimation of the severity of coronary artery stenosis. Eleven patients underwent adenosine triphosphate (0.16 mg/kg/min, 5 min) stress dynamic CTP by 256-slice CT (coverage: 8 cm, 0.27 s/rotation), and 9 of the 11 patients underwent coronary angiography (CAG). Stress dynamic CTP (whole–heart datasets over 30 consecutive heart beats in systole without spatial and temporal gaps) was acquired with prospective ECG gating (effective radiation dose: 10.4 mSv). The extent of HPAs was visually graded using a 3-point score (normal, subendocardial, transmural). MBF (ml/100g/min) was measured by deconvolution. Differences in MBF (mean ± standard error) according to HPA and CAG results were evaluated. In 27 regions (3 major coronary territories in 9 patients), 11 coronary stenoses (> 50% reduction in diameter) were observed. In 353 myocardial segments, HPA was significantly related to MBF (P < 0.05; normal 295 ± 94; subendocardial 186 ± 67; and transmural 80 ± 53). Coronary territory analysis revealed a significant relationship between coronary stenosis severity and MBF (P < 0.05; non-significant stenosis [< 50%], 284 ± 97; moderate stenosis [50–70%], 184 ± 74; and severe stenosis [> 70%], 119 ± 69). The qualitative transmural extent of HPA using stress whole-heart dynamic CTP imaging by 256-slice CT exhibits a good correlation with quantitative CTP-derived MBF and may aid in assessing the hemodynamic significance of coronary artery disease.
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影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
3.3
作者：
MEIER, P;ZIERLER, KL
通讯作者：
ZIERLER, KL
DOI：
10.1016/0735-1097(94)00523-s
发表时间：
1995-04-01
影响因子：
24
作者：
PALMAS, W;FRIEDMAN, JD;BERMAN, DS
通讯作者：
BERMAN, DS
影响因子：
6.2
作者：
Rossi, Alexia;Uitterdijk, Andre;Merkus, Daphne
通讯作者：
Merkus, Daphne
影响因子：
5
作者：
Sakuma, H;Suzawa, N;Takeda, K
通讯作者：
Takeda, K