Nanoelectroablation of human pancreatic carcinoma in a murine xenograft model without recurrence.
Nanoelectroablation of human pancreatic carcinoma in a murine xenograft model without recurrence.
复制标题
DOI：
10.1002/ijc.27860
复制
发表时间：
2013-04-15
影响因子：
6.4
通讯作者：
Nuccitelli, Pamela
中科院分区：
文献类型：
--
作者：
Nuccitelli, Richard;Huynh, Joanne;Lui, Kaying;Wood, Ryan;Kreis, Mark;Athos, Brian;Nuccitelli, Pamela
我们已经确定了一种在小鼠异种移植模型中治疗胰腺癌的有效纳米电消融疗法。这种疗法通过对肿瘤施加100 ns长、幅度为30千伏/厘米的低能量电脉冲，以非热的方式启动细胞凋亡。我们首先通过治疗30个肿瘤确定了完全消融所需的最小脉冲数。我们发现，一次治疗肿瘤所需的最小脉冲数量在250到500个脉冲之间。我们决定对19只NIH-III小鼠单一应用500或1000脉冲治疗胰腺癌。19个接受治疗的肿瘤中有17个肿瘤完全消退，无复发。3只小鼠在治疗后3个月内因不明原因死亡，16只存活270-302天，我们在此期间处死它们进行组织学分析。在17个未经治疗的对照组中，肿瘤变得如此之大，以至于我们不得不在4个月内将它们全部切除。
We have identified an effective nanoelectroablation therapy for treating pancreatic carcinoma in a murine xenograft model. This therapy initiates apoptosis in a nonthermal manner by applying low energy electric pulses 100 ns long and 30 kV/cm in amplitude to the tumor. We first identified the minimum pulse number required for complete ablation by treating 30 tumors. We found that the minimum number of pulses required to ablate the tumor with a single treatment is between 250 and 500 pulses. We settled on a single application of either 500 or 1000 pulses to treat pancreatic carcinomas in 19 NIH-III mice. Seventeen of the 19 treated tumors exhibited complete regression without recurrence. Three mice died of unknown causes within 3 months after treatment but 16 lived for 270–302 days at which time we sacrificed them for histological analysis. In the 17 untreated controls, the tumor grew so large that we had to sacrifice all of them within 4 months.
登录
查看更多内容
影响因子：
5
作者：
Ibey, Bennett L.;Mixon, Dustin G.;Payne, Jason A.;Bowman, Angela;Sickendick, Karl;Wilmink, Gerald J.;Roach, W. Patrick;Pakhomov, Andrei G.
通讯作者：
Pakhomov, Andrei G.
影响因子：
3.9
作者：
Pakhomova, Olga N.;Khorokhorina, Vera A.;Bowman, Angela M.;Rodaite-Riseviciene, Raminta;Saulis, Gintautas;Xiao, Shu;Pakhomov, Andrei G.
通讯作者：
Pakhomov, Andrei G.
影响因子：
4.3
作者：
Nuccitelli R;Tran K;Lui K;Huynh J;Athos B;Kreis M;Nuccitelli P;De Fabo EC
通讯作者：
De Fabo EC
影响因子：
3.7
作者：
Feng, W;Wang, ZB;Su, HB
通讯作者：
Su, HB
影响因子：
2.4
作者：
Levine, Zachary A.;Vernier, P. Thomas
通讯作者：
Vernier, P. Thomas