A knock-in Foxj1(CreERT2::GFP) mouse for recombination in epithelial cells with motile cilia.
A knock-in Foxj1(CreERT2::GFP) mouse for recombination in epithelial cells with motile cilia.
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DOI：
10.1002/dvg.22753
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发表时间：
2014-04
期刊：
影响因子：
1.5
通讯作者：
Ghashghaei, H. Troy
中科院分区：
文献类型：
--
作者：
Muthusamy, Nagendran;Vijayakumar, Akshitha;Cheng, Gang, Jr.;Ghashghaei, H. Troy
The transcription factor Foxj1 is expressed by cells destined to differentiate into epithelial cells projecting motile cilia into fluid- or air- filled cavities. Here we report the generation of an inducible knock-in Foxj1CreERT2::GFP mouse which we show reliably induces Cre-mediated recombination for genetic studies in epithelial cells with motile cilia throughout embryonic and postnatal development. Induction during embryonic stages revealed efficient recombination in the epithelial component of the choroid plexus in the developing brain as early as E12.5. Induction during late embryonic stages showed confined recombination not only in the choroid plexus, but also in the ventricular walls of the brain. Recombination induced during postnatal periods expanded to include epithelia of the lungs, testis, oviduct, and brain. Using these mice, we confirmed our recent discovery of a perinatally derived neuronal population in the mouse olfactory bulbs which is derived from the Foxj1 lineage. Our Foxj1CreERT2::GFP knock-in mouse will be a powerful tool for studying molecular mechanisms associated with the continuum of cells that form the Foxj1 lineage, and for assessing their physiological significance during development and aging.
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DOI：
10.1073/pnas.94.7.3094
发表时间：
1997-04-01
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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Kuo CT
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Ghashghaei, H. Troy
DOI：
10.1165/ajrcmb.23.1.4070
发表时间：
2000-07-01
影响因子：
6.4
作者：
Brody, SL;Yan, XH;Shapiro, SD
通讯作者：
Shapiro, SD
DOI：
10.1523/jneurosci.0171-11.2011
发表时间：
2011-06-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jacquet BV;Muthusamy N;Sommerville LJ;Xiao G;Liang H;Zhang Y;Holtzman MJ;Ghashghaei HT
通讯作者：
Ghashghaei HT