Ank3-dependent SVZ niche assembly is required for the continued production of new neurons.
Ank3-dependent SVZ niche assembly is required for the continued production of new neurons.
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DOI：
10.1016/j.neuron.2011.05.029
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发表时间：
2011-07-14
期刊：
影响因子：
16.2
通讯作者：
Kuo CT
中科院分区：
文献类型：
--
作者：
Paez-Gonzalez P;Abdi K;Luciano D;Liu Y;Soriano-Navarro M;Rawlins E;Bennett V;Garcia-Verdugo JM;Kuo CT
The rodent subventricular/subependymal zone (SVZ/SEZ) houses neural stem cells (NSCs) that generate olfactory bulb interneurons. It is unclear how the SVZ environment sustains neuronal production into adulthood. We discovered that the adapter molecule Ankyrin-3 (Ank3) is specifically upregulated in radial glia destined to become SVZ ependymal niche cells, but not in NSCs, and is required for SVZ assembly through progenitor lateral adhesion. Furthermore, we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation, and genetic deletion of this pathway led to complete loss of SVZ niche structure. In its absence, radial glia continued to transition into postnatal NSCs. However, inducible ependymal deletion of Foxj1-Ank3 after SVZ niche assembly resulted in dramatic depletion of neurogenesis. Targeting a novel pathway regulating ependymal organization/assembly and showing its requirement for new neuron production, our results have important implications for environmental control of adult neurogenesis and harvesting NSCs for replacement therapy.
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影响因子：
64.5
作者：
Kuo, Chay T.;Mirzadeh, Zaman;Jan, Yuh-Nung
通讯作者：
Jan, Yuh-Nung
DOI：
10.1126/science.1162327
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badis G;Berger MF;Philippakis AA;Talukder S;Gehrke AR;Jaeger SA;Chan ET;Metzler G;Vedenko A;Chen X;Kuznetsov H;Wang CF;Coburn D;Newburger DE;Morris Q;Hughes TR;Bulyk ML
通讯作者：
Bulyk ML
DOI：
10.1073/pnas.94.7.3094
发表时间：
1997-04-01
影响因子：
11.1
作者：
Lim, L;Zhou, HP;Costa, RH
通讯作者：
Costa, RH
影响因子：
3.3
作者：
Abdi, Khadar M.;Bennett, Vann
通讯作者：
Bennett, Vann
影响因子：
13.9
作者：
Kriegstein A;Alvarez-Buylla A
通讯作者：
Alvarez-Buylla A