Liver 'organ on a chip'.
Liver 'organ on a chip'.
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DOI：
10.1016/j.yexcr.2017.12.023
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发表时间：
2018-02-01
影响因子：
3.7
通讯作者：
Wells A
中科院分区：
文献类型：
--
作者：
Beckwitt CH;Clark AM;Wheeler S;Taylor DL;Stolz DB;Griffith L;Wells A
肝脏在体内平衡和病理学中起着关键作用。它是体内药物代谢的主要部位，因此是药物诱导毒性的常见靶点，易患多种疾病。与其他实体器官相比，肝脏具有独特的再生能力。该器官的生理重要性和可塑性使其成为更好地了解人类生理学，疾病和对外源性化合物反应的重要研究系统。这篇评论的目的是告知读者的意义和可用的方法复制人类肝脏的生理和病理离体。首先，将讨论肝脏及其细胞成分的生理作用。其次，我们将讨论开发离体肝脏系统的必要性。第三，将提及用于填充系统的不同细胞来源的优点和缺点。第四，将讨论目前采用的离体肝培养系统（商业上可获得的和在研究实验室中使用的）的好处。最后，未来的方向，以推进这些系统，包括复杂的肝脏培养系统与其他器官为基础的培养系统（“器官芯片”），将提出。
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity of this organ make it a crucial system of study to better understand human physiology, disease, and response to exogenous compounds. The purpose of this review is to inform the reader of the significance and available methods for replicating human liver physiology and pathology ex vivo. First, the physiologic roles of the liver and its cellular constituents will be discussed. Second, we will discuss the need for developing an ex vivo liver system. Third, the advantages and disadvantages of different cell sources used to populate the system will be mentioned. Fourth, the benefits of currently employed ex vivo liver culture systems (both commercially available and used in research laboratories) will be discussed. Finally, future directions to advance these systems, including complexing liver culture systems with other organ-based culture systems (“organ chips”), will be proposed.
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影响因子：
7.5
作者：
Bhushan A;Senutovitch N;Bale SS;McCarty WJ;Hegde M;Jindal R;Golberg I;Berk Usta O;Yarmush ML;Vernetti L;Gough A;Bakan A;Shun TY;DeBiasio R;Lansing Taylor D
通讯作者：
Lansing Taylor D
影响因子：
2.1
作者：
Baillie TA;Rettie AE
通讯作者：
Rettie AE
影响因子：
3.9
作者：
Dixit, Vaishali;Moore, Amanda;Hariparsad, Niresh
通讯作者：
Hariparsad, Niresh
影响因子：
3.9
作者：
Chan, Tom S.;Yu, Hongbin;Tweedie, Donald
通讯作者：
Tweedie, Donald
影响因子：
2.7
作者：
Cho CH;Park J;Tilles AW;Berthiaume F;Toner M;Yarmush ML
通讯作者：
Yarmush ML