Colorectal Chemoprevention Pilot Study (SWOG-9041), randomized and placebo controlled: the importance of multiple luminal lesions.
Colorectal Chemoprevention Pilot Study (SWOG-9041), randomized and placebo controlled: the importance of multiple luminal lesions.
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DOI：
10.1016/j.clcc.2011.06.005
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发表时间：
2011-12
影响因子：
3.4
通讯作者：
Goodman GE
中科院分区：
文献类型：
--
作者：
Chu DZ;Hussey MA;Alberts DS;Meyskens FL Jr;Fenoglio-Preiser CM;Rivkin SE;Mills GM;Giguere JK;Blanke CD;Goodman GE
在切除的结直肠癌患者中进行的初步随机安慰剂对照化学预防试验证明了同步腺瘤的重要性和口服碳酸钙的潜在作用。结直肠癌在世界范围内很常见，化学预防有可能减少可能患有这种疾病并死于这种疾病的人数。在一个多机构肿瘤学研究组中，使用碳酸钙作为试验药物，在结直肠癌患者中进行了一项随机安慰剂对照初步研究。220名志愿者在研究中被随机分配。主要目标的遵守，应计，和毒性监测。记录研究入组时存在多发性腺瘤和随后发生异时性腺瘤，发现与同步性腺瘤相关。复发性腺瘤的次要终点表明，随机分配至钙组的志愿者新发腺瘤的发生率较低。这项初步研究表明，在结直肠肿瘤化学预防临床试验中招募结直肠癌幸存者作为研究志愿者的可行性，口服钙仍然是减少结直肠腺瘤的潜在有效药物。
Pilot randomized placebo controlled chemoprevention trial in resected colorectal cancer patients demonstrated importance of synchronous adenomas and potential effects of oral calcium carbonate. Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease. A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas.
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影响因子：
158.5
作者：
Sandler, RS;Halabi, S;Schilsky, R
通讯作者：
Schilsky, R
影响因子：
3.2
作者：
Hofstad, B;Almendingen, K;Osnes, M
通讯作者：
Osnes, M
影响因子：
158.5
作者：
Chlebowski, RT;Wactawski-Wende, J;Carleton, R
通讯作者：
Carleton, R
影响因子：
7.1
作者：
Peters, U;Chatterjee, N;Hayes, RB
通讯作者：
Hayes, RB
影响因子：
3.7
作者：
Chu, DZJ;Chansky, K;Lippman, SM
通讯作者：
Lippman, SM