Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch.
Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch.
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DOI：
10.1007/s00281-009-0192-1
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发表时间：
2010-06
影响因子：
9
通讯作者：
Liu, Yun-Cai
中科院分区：
文献类型：
--
作者：
Su, Jin;Liu, Yun-Cai
调节性T细胞(Tregs)在维持对自身抗原的免疫耐受中起关键作用，其发育和激活受主要调节因子和转录因子Foxp3的控制。Foxp3作为转录抑制因子，通过直接与其他转录调控因子结合和抑制来发挥其抑制作用。FOXP3的基因转录受多种细胞和分子机制的调控，其中包括多效性细胞因子转化生长因子-β(TGFR-β)。瘙痒是一种E3泛素连接酶，其缺陷与免疫反应过度、T辅助细胞分化异常和T细胞无能诱导失败有关。最近的证据表明，Ich参与了转化生长因子-β诱导的Foxp3表达和Treg调节的气道炎症，从而确定了一条泛素依赖的调节Treg的途径。
Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance to self-antigens, whose development and activation is controlled by the master regulator and transcription factor Foxp3. Foxp3 acts as transcription repressor and exerts its suppressing function via directly associating with and inhibiting the function of other transcriptional regulators. The gene transcription of Foxp3 is regulated by diverse mechanisms at the cellular and molecular levels including the pleiotropic cytokine transforming growth factor-β (TGF-β). Itch is an E3 ubiquitin ligase whose deficiency is linked to excessive immune responses, abnormal T helper cell differentiation, and failed T cell anergy induction. Recent evidence indicates that Itch is involved in TGF-β-induced Foxp3 expression and Treg-regulated airway inflammation, thus identifying a ubiquitin-dependent pathway in modulating Tregs.
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影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
影响因子：
64.5
作者：
Dasen, Jeremy S.;De Camilli, Alessandro;Jessell, Thomas M.
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Jessell, Thomas M.
影响因子：
4.4
作者：
Gorelik, L;Fields, PE;Flavell, RA
通讯作者：
Flavell, RA
DOI：
10.1073/pnas.0509484103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Gavin, MA;Torgerson, TR;Rudensky, AY
通讯作者：
Rudensky, AY
DOI：
10.1073/pnas.91.1.38
发表时间：
1994-01-04
影响因子：
11.1
作者：
GAJEWSKI, TF;QIAN, DP;FITCH, FW
通讯作者：
FITCH, FW