The heritability of schizophrenia and schizoaffective disorder. A family study.

The heritability of schizophrenia and schizoaffective disorder. A family study.
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精神分裂症和分裂情感障碍的遗传性。

DOI:
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发表时间:
1988
影响因子:
--
通讯作者:
M. Zimmerman
M. Zimmerman
中科院分区:
--
文献类型:
--
作者:
W. Coryell;M. Zimmerman

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91名连续入院的精神分裂症患者(n = 21)、分裂情感性抑郁症(n = 43)或精神病性抑郁症(n = 27)与36名从未患病的对照组一起进入了一项盲人家庭研究。虽然精神分裂症谱系障碍聚集在家庭中,但它们在精神分裂症先证者家庭中并不明显更普遍。相比之下,情感障碍的发病风险明显将精神抑郁先证者的家庭与精神分裂症和对照组的家庭区分开来。分裂情感性先证者的家庭研究数据表明,分裂情感性先证者与情感障碍和精神分裂症都有联系,同时也表明,少数分裂情感性障碍患者可能携带两种疾病的遗传倾向。
Ninety-one consecutively admitted patients with schizophrenia (n = 21), schizoaffective depression (n = 43), or psychotic depression (n = 27) entered a blind family study along with 36 never-ill controls. Though schizophrenia spectrum disorders clustered within families, they were not significantly more prevalent in the families of schizophrenic probands. In contrast, morbid risks for affective disorder clearly separated the families of psychotically depressed probands from the families of both schizophrenics and controls. Family study data for schizoaffective probands indicated links to both affective disorder and schizophrenia and suggested, as well, that a small number of patients with schizoaffective disorder may carry a genetic liability to both conditions.
精神分裂症和正常对照先证者的家庭研究:对精神分裂症谱系概念的影响。
DOI: 10.1176/ajp.142.4.447
发表时间: 1985
期刊: The American journal of psychiatry
影响因子: --
作者:
Baron,M;Gruen,R;Rainer,JD;Kane,J;Asnis,L;Lord,S
通讯作者: Lord,S
分裂情感性、精神病性和非精神病性抑郁症:不同的家族关联。
DOI: 10.1016/0010-440x(86)90064-7
发表时间: 1986
影响因子: 7.3
作者:
Endicott,J;Nee,J;Coryell,W;Keller,M;Andreasen,N;Croughan,J
通讯作者: Croughan,J