A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia.

A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia.
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精神分裂症和正常对照先证者的家庭研究:对精神分裂症谱系概念的影响。

DOI:
10.1176/ajp.142.4.447
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发表时间:
1985
期刊:
The American journal of psychiatry
影响因子:
--
通讯作者:
Lord,S
Lord,S
中科院分区:
--
文献类型:
--
作者:
Baron,M;Gruen,R;Rainer,JD;Kane,J;Asnis,L;Lord,S

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在750名慢性精神分裂症患者和正常对照先证者的一级亲属中确定了精神疾病的发病风险。精神分裂症先证者的亲属比正常对照先证者的亲属更常见的精神障碍是慢性精神分裂症(5.8%比0.6%),典型人格障碍(明确,14.6%比2.1%;可能,12.1%比6.5%)和偏执型人格障碍(7.3%比2.3%)。这些数据表明,典型和偏执型人格障碍与精神分裂症有遗传关系。精神分裂症研究的影响进行了讨论。
Morbidity risks for mental illness were determined in 750 first-degree relatives of chronic schizophrenic and normal control probands. Psychiatric disorders that were more frequent in relatives of schizophrenic probands than in relatives of normal control probands were chronic schizophrenia(5.8% versus 0.6%), schizotypal personality disorder(definite, 14.6% versus 2.1%; probable, 12.1% versus 6.5%), and paranoid personality disorder(7.3% versus 2.3%). The data suggest that schizotypal and paranoid personality disorders are genetically related to schizophrenia. The implications for schizophrenia research are discussed.
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