First trimester maternal medication use in relation to gastroschisis.
First trimester maternal medication use in relation to gastroschisis.
复制标题
妊娠早期母亲使用与腹裂相关的药物。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
S. Shapiro
中科院分区：
文献类型：
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作者：
M. Werler;A. Mitchell;S. Shapiro
在病例对照监测项目中，研究了妊娠早期药物使用与腹裂的关系。有76例腹裂与2,142例其他主要畸形的对照进行了比较。对于使用伪麻黄碱，我们发现相对危险度显著升高，为3.2（95%置信区间，1.3-7.7），调整了混杂因素。镇痛药/解热药和另一种减充血剂的多变量相对风险如下：水杨酸盐，1.6（0.9-2.7）;对乙酰氨基酚，1.7（1.0-2.9）;布洛芬，1.3（0.4-3.7）;苯丙醇胺，1.5（0.4-5.4）。未发现使用抗组胺药、抗生素、口服避孕药或杀精剂的风险增加。由于水杨酸盐、伪麻黄碱和苯丙醇胺具有血管活性，这些药物的风险升高支持腹裂病因学中血管破坏的假设。因此，我们研究了与第二个病例组416名怀疑有血管病因的异质性缺陷婴儿有关的母亲使用血管活性药物的情况。水杨酸盐、布洛芬、伪麻黄碱、苯丙醇胺和其他减充血剂的相对风险接近于1。这些积极的联系必须被认为是暂时的。以前没有报道过，应该独立确认。此外，对乙酰氨基酚，可以采取相同的适应症作为水杨酸盐和减充血剂，但不被认为是血管活性，与腹裂，这表明确定的关联可能是由于潜在的母亲疾病。
In a case-control surveillance program, first trimester medication use was studied in relation to gastroschisis. There were 76 cases of gastroschisis which were compared with 2,142 controls with other major malformations. For pseudoephedrine use, we found a significantly elevated relative risk of 3.2 (95% confidence interval, 1.3-7.7), with adjustment for confounding. Multivariate relative risks for analgesic/antipyretics and another decongestant were as follows: salicylates, 1.6 (0.9-2.7); acetaminophen, 1.7 (1.0-2.9); ibuprofen, 1.3 (0.4-3.7); and phenylpropanolamine, 1.5 (0.4-5.4). No increases in risk were identified for use of antihistamines, antibiotics, oral contraceptives, or spermicides. Because salicylates, pseudoephedrine, and phenylpropanolamine are vasoactive, the elevated risks for these drugs support the hypothesis of vascular disruption in the etiology of gastroschisis. We therefore examined maternal use of vasoactive medications in relation to a second case group of 416 infants with hetereogeneous defects suspected to have a vascular etiology. Relative risks for salicylates, ibuprofen, pseudoephedrine, phenylpropanolamine, and other decongestants approximated unity. These positive associations must be considered tentative. They have not been reported previously and should be confirmed independently. Also, acetaminophen, which may be taken for the same indications as salicylates and decongestants, but is not thought to be vasoactive, was associated with gastroschisis, suggesting that identified associations may be due to an underlying maternal illness.
母亲使用可卡因和泌尿生殖道畸形。
DOI：
10.1002/tera.1420370304
发表时间：
1988
期刊：
Teratology
影响因子：
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作者：
Chasnoff,IJ;Chisum,GM;Kaplan,WE
通讯作者：
Kaplan,WE