Maternal cocaine use and genitourinary tract malformations.

Maternal cocaine use and genitourinary tract malformations.
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母亲使用可卡因和泌尿生殖道畸形。

DOI:
10.1002/tera.1420370304
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发表时间:
1988
期刊:
Teratology
影响因子:
--
通讯作者:
Kaplan,WE
Kaplan,WE
中科院分区:
--
文献类型:
--
作者:
Chasnoff,IJ;Chisum,GM;Kaplan,WE

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一个特定的胎儿破坏综合征与母亲使用可卡因尚未被记录。在我们的化学依赖性妇女项目中评估的前23例妊娠中,一名患有梅干腹综合征的婴儿和一名患有尿道下裂的婴儿被交付给使用可卡因的妇女。在本研究中,所有在我们项目中分娩的婴儿在出生后2-3天接受肾脏超声检查。对50名使用可卡因的妇女(第一组)和30名使用多种药物的非可卡因妇女(第二组)所生的婴儿进行了评估。这两组女性在年龄、妊娠和种族方面相似。两组婴儿的平均出生体重相似。第一组中有7名婴儿出现泌尿生殖道畸形,而第二组中没有婴儿出现此类畸形。假设可卡因的血管收缩作用可以解释暴露于可卡因的婴儿中发现的泌尿生殖道异常。
A specific fetal disruption syndrome associated with maternal cocaine use has not as yet been documented. In the first 23 pregnancies evaluated in our program for chemically dependent women, one infant with prune belly syndrome and one infant with hypospadias were delivered to cocaine‐using women. In the present study, all infants delivered in our program received a renal ultrasound at 2–3 days of life. Fifty infants born to cocaine‐using women (group I) and 30 born to polydrug, noncocaine‐using women (group II) were evaluated. The two groups of women were similar for age, gravidity, and race. Mean birth weight of the infants in the two groups was similar. Seven infants in group I demonstrated genitourinary tract malformations while there were no infants with such malformations in group II. It is hypothesized that the vasoconstrictive effects of cocaine could explain the abnormalities of the genitourinary tract found in the cocaine‐exposed infants.
梅腹综合征的发病机制:前列腺发育不全引起的功能性尿道梗阻。
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作者:
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