CEST phase mapping using a length and offset varied saturation (LOVARS) scheme.
CEST phase mapping using a length and offset varied saturation (LOVARS) scheme.
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DOI：
10.1002/mrm.23312
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发表时间：
2012-10
影响因子：
3.3
通讯作者：
McMahon, Michael T.
中科院分区：
文献类型：
--
作者：
Song, Xiaolei;Gilad, Assaf A.;Joel, Suresh;Liu, Guanshu;Bar-Shir, Amnon;Liang, Yajie;Gorelik, Michael;Pekar, James J.;van Zijl, Peter C. M.;Bulte, Jeff W. M.;McMahon, Michael T.
关键词：
化学交换满意度转移（CEST）MRI是细胞和分子成像的有望的新技术。交换对比的特性和满意度频率为了检测CEST的对比，在这里提出了“长度和偏移变化的饱和度”或“ LOVAR”，该图像获得了一组具有饱和参数的图像，以调节交换对比度。将调制模式分解为转化后的单独的水信号损失来源。增量校正，结果表明，LOVAR相位映射获得了CNR的四倍，并且表现出较少的B0伪像。
Chemical exchange saturation transfer (CEST) MRI is a promising new technique for cellular and molecular imaging. This contrast allows the detection of tumors and ischemia without the use of gadolinium as well as the design of microenvironment-sensitive probes that can be discriminated based on their exchange contrast properties and saturation frequency. Current acquisition schemes to detect and analyze this contrast suffer from sensitivity to spatial B0 inhomogeneity and low contrast-to-noise-ratio (CNR), which is an obstacle to widespread adoption of the technology. A new method to detect CEST contrast is proposed here, termed “Length and Offset VARied Saturation” or “LOVARS”, which acquires a set of images with the saturation parameters varied so as to modulate the exchange contrast. Either fast fourier transform or the general linear model can be employed to decompose the modulation patterns into separate sources of water signal loss. After transformation, a LOVARS phase map is generated, which is insensitive to B0 inhomogeneity. When collected on live mice bearing 9L gliosarcomas, and compared to the conventional MTRasym map using offset increment correction, the results show that LOVARS phase mapping obtains about four times higher CNR and exhibits less B0 artifacts.
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影响因子：
--
作者：
Li Y;Sheth VR;Liu G;Pagel MD
通讯作者：
Pagel MD
影响因子：
15
作者：
Liu, Guanshu;Liang, Yajie;Bar-Shir, Amnon;Chan, Kannie W. Y.;Galpoththawela, Chulani S.;Bernard, Segun M.;Tse, Terence;Yadav, Nirbhay N.;Walczak, Piotr;McMahon, Michael T.;Bulte, Jeff W. M.;van Zijl, Peter C. M.;Gilad, Assaf A.
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通讯作者：
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