DNA Methylation Sustains "Inflamed" Memory of Peripheral Immune Cells Aggravating Kidney Inflammatory Response in Chronic Kidney Disease.
DNA Methylation Sustains "Inflamed" Memory of Peripheral Immune Cells Aggravating Kidney Inflammatory Response in Chronic Kidney Disease.
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DNA 甲基化维持外周免疫细胞的“炎症”记忆，加重慢性肾病患者的肾脏炎症反应。
DOI：
10.3389/fphys.2021.637480
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发表时间：
2021
影响因子：
4
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Chen XJ;Zhang H;Yang F;Liu Y;Chen G
在过去的几十年里，慢性肾脏病（CKD）的发病率迅速增加。进行性肾功能丧失是CKD的一部分特征，即使接受了强化支持治疗。无论其病因如何，CKD进展通常伴随慢性肾脏炎症的发展，慢性肾脏炎症的病理特征是招募的免疫细胞的低度但慢性活化。累积的证据支持多种外周免疫细胞（包括T细胞和单核细胞）的异常DNA甲基化模式与许多慢性疾病环境中的CKD发展密切相关。DNA甲基化谱的改变可以持续很长时间，并影响循环免疫细胞中未来的基因表达，即使它们从循环迁移到受累的肾脏。揭示改变的DNA甲基化如何调节募集的效应细胞中炎症反应的强度和时间长度的潜在机制具有临床意义。我们和其他人最近证明，改变的DNA甲基化发生在外周免疫细胞中，并深刻地促进了系统性慢性疾病（如糖尿病和高血压）中CKD的发展。本文将总结目前关于异常DNA甲基化对循环免疫细胞的影响以及它如何潜在地决定CKD的结果的研究结果。
The incidence of chronic kidney disease (CKD) has rapidly increased in the past decades. A progressive loss of kidney function characterizes a part of CKD even with intensive supportive treatment. Irrespective of its etiology, CKD progression is generally accompanied with the development of chronic kidney inflammation that is pathologically featured by the low-grade but chronic activation of recruited immune cells. Cumulative evidence support that aberrant DNA methylation pattern of diverse peripheral immune cells, including T cells and monocytes, is closely associated with CKD development in many chronic disease settings. The change of DNA methylation profile can sustain for a long time and affect the future genes expression in the circulating immune cells even after they migrate from the circulation into the involved kidney. It is of clinical interest to reveal the underlying mechanism of how altered DNA methylation regulates the intensity and the time length of the inflammatory response in the recruited effector cells. We and others recently demonstrated that altered DNA methylation occurs in peripheral immune cells and profoundly contributes to CKD development in systemic chronic diseases, such as diabetes and hypertension. This review will summarize the current findings about the influence of aberrant DNA methylation on circulating immune cells and how it potentially determines the outcome of CKD.
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影响因子：
3.5
作者：
Fali T;Le Dantec C;Thabet Y;Jousse S;Hanrotel C;Youinou P;Brooks WH;Perl A;Renaudineau Y
通讯作者：
Renaudineau Y
影响因子：
16.6
作者：
Chu AY;Tin A;Schlosser P;Ko YA;Qiu C;Yao C;Joehanes R;Grams ME;Liang L;Gluck CA;Liu C;Coresh J;Hwang SJ;Levy D;Boerwinkle E;Pankow JS;Yang Q;Fornage M;Fox CS;Susztak K;Köttgen A
通讯作者：
Köttgen A
影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali
影响因子：
8.3
作者：
Chen, Jing;Bundy, Joshua D.;Townsend, Raymond R.
通讯作者：
Townsend, Raymond R.
影响因子：
3.9
作者：
Bennett, Jeanette M.;Reeves, Glenn;Sturmberg, Joachim P.
通讯作者：
Sturmberg, Joachim P.