An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation.
An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation.
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DOI：
10.3389/fonc.2020.608923
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发表时间：
2020
影响因子：
4.7
通讯作者：
Markey KA
中科院分区：
文献类型：
--
作者：
Andrlová H;van den Brink MRM;Markey KA
异基因造血细胞移植（allo-HCT）是恶性血液病和非恶性血液病、免疫学和代谢疾病的治疗目的，然而，其更广泛的实施受到移植相关并发症发生率高和2年死亡率接近50%的限制。功能性先天和适应性免疫系统的稳健重建是良好的长期患者结局的关键因素，主要是为了预防和克服移植后感染并发症，并确保足够的移植物抗白血病效应。越来越多的证据表明，非常规T细胞在allo-HCT后可能具有重要的免疫调节作用，这可能至少部分依赖于移植后肠道微生物组。在这里，我们讨论了免疫重建在allo-HCT结果中的作用，重点是非常规T细胞，特别是粘膜相关的不变T（MAIT）细胞，γδ（gd）T细胞和不变NK T（iNKT）细胞。我们提供了一个概述的机制，临床前和相关的临床研究已经进行。我们还讨论了肠道微生物组在造血功能和整体免疫重建方面的新作用。
Allogeneic hematopoietic cell transplantation (allo-HCT) is performed as curative-intent therapy for hematologic malignancies and non-malignant hematologic, immunological and metabolic disorders, however, its broader implementation is limited by high rates of transplantation-related complications and a 2-year mortality that approaches 50%. Robust reconstitution of a functioning innate and adaptive immune system is a critical contributor to good long-term patient outcomes, primarily to prevent and overcome post-transplantation infectious complications and ensure adequate graft-versus-leukemia effects. There is increasing evidence that unconventional T cells may have an important immunomodulatory role after allo-HCT, which may be at least partially dependent on the post-transplantation intestinal microbiome. Here we discuss the role of immune reconstitution in allo-HCT outcome, focusing on unconventional T cells, specifically mucosal-associated invariant T (MAIT) cells, γδ (gd) T cells, and invariant NK T (iNKT) cells. We provide an overview of the mechanistic preclinical and associative clinical studies that have been performed. We also discuss the emerging role of the intestinal microbiome with regard to hematopoietic function and overall immune reconstitution.
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影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
DOI：
10.1084/jem.20171739
发表时间：
2018-02-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ben Youssef G;Tourret M;Salou M;Ghazarian L;Houdouin V;Mondot S;Mburu Y;Lambert M;Azarnoush S;Diana JS;Virlouvet AL;Peuchmaur M;Schmitz T;Dalle JH;Lantz O;Biran V;Caillat-Zucman S
通讯作者：
Caillat-Zucman S
影响因子：
7.2
作者：
Correia DV;Lopes A;Silva-Santos B
通讯作者：
Silva-Santos B
DOI：
10.1126/science.aax6624
发表时间：
2019-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinides MG;Link VM;Tamoutounour S;Wong AC;Perez-Chaparro PJ;Han SJ;Chen YE;Li K;Farhat S;Weckel A;Krishnamurthy SR;Vujkovic-Cvijin I;Linehan JL;Bouladoux N;Merrill ED;Roy S;Cua DJ;Adams EJ;Bhandoola A;Scharschmidt TC;Aubé J;Fischbach MA;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
20.3
作者：
Correia, Daniel V.;Fogli, Manuela;Silva-Santos, Bruno
通讯作者：
Silva-Santos, Bruno