Ontogeny of human mucosal-associated invariant T cells and related T cell subsets.
Ontogeny of human mucosal-associated invariant T cells and related T cell subsets.
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DOI：
10.1084/jem.20171739
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发表时间：
2018-02-05
期刊：
影响因子：
--
通讯作者：
Caillat-Zucman S
中科院分区：
文献类型：
--
作者：
Ben Youssef G;Tourret M;Salou M;Ghazarian L;Houdouin V;Mondot S;Mburu Y;Lambert M;Azarnoush S;Diana JS;Virlouvet AL;Peuchmaur M;Schmitz T;Dalle JH;Lantz O;Biran V;Caillat-Zucman S
脐带血中的MAIT细胞很少。Ben Youssef等人表明，它们在儿童时期缓慢扩增，并指出TCRαβ库在确定其识别MR 1限制性微生物抗原的独特能力方面发挥关键作用。粘膜相关不变T（MAIT）细胞是半不变的Vα7.2+ CD 161 highCD 4 − T细胞，可识别微生物核黄素前体衍生物，如MR 1呈递的5-OP-RU。人MAIT细胞在成人血液中丰富，但在脐带血中很少。我们纵向研究了婴儿期和脐血移植后Vα7.2+ CD 161 high T细胞和相关亚群水平。我们发现Vα7.2+和Vα7.2− CD 161 high T细胞在妊娠早期产生，并且可能具有共同的产前发育程序。在脐带血Vα7.2+ CD 161 high T细胞中，少数识别MR 1：5-OP-RU的T细胞显示出与成人MAIT细胞非常相似的TRAV/TRBV库。在出生后几周内，只有MR 1：5-OP-RU反应性Vα7.2+ CD 161 high T细胞获得记忆表型。只有这些细胞扩增形成成人MAIT池，稀释其他Vα7.2+ CD 161 high和Vα7.2− CD 161 high群体，这个过程需要至少6年才能达到成人水平。因此，成年MAIT细胞的高克隆大小是抗原驱动的，可能是由于TCRαβ链识别MR 1限制性微生物抗原的良好特异性。
There are very few human MAIT cells in cord blood. Ben Youssef et al. show that they slowly expand during childhood and point to a critical role of the TCRαβ repertoire in determining their unique ability to recognize MR1-restricted microbial antigens. Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7.2+ CD161highCD4− T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are very few in cord blood. We longitudinally studied Vα7.2+ CD161high T cell and related subset levels in infancy and after cord blood transplantation. We show that Vα7.2+ and Vα7.2− CD161high T cells are generated early during gestation and likely share a common prenatal developmental program. Among cord blood Vα7.2+ CD161high T cells, the minority recognizing MR1:5-OP-RU display a TRAV/TRBV repertoire very similar to adult MAIT cells. Within a few weeks of life, only the MR1:5-OP-RU reactive Vα7.2+ CD161high T cells acquire a memory phenotype. Only these cells expand to form the adult MAIT pool, diluting out other Vα7.2+ CD161high and Vα7.2− CD161high populations, in a process requiring at least 6 years to reach adult levels. Thus, the high clonal size of adult MAIT cells is antigen-driven and likely due to the fine specificity of the TCRαβ chains recognizing MR1-restricted microbial antigens.
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影响因子：
8
作者：
Fergusson JR;Hühn MH;Swadling L;Walker LJ;Kurioka A;Llibre A;Bertoletti A;Holländer G;Newell EW;Davis MM;Sverremark-Ekström E;Powrie F;Capone S;Folgori A;Barnes E;Willberg CB;Ussher JE;Klenerman P
通讯作者：
Klenerman P
影响因子：
46.9
作者：
Han, Arnold;Glanville, Jacob;Hansmann, Leo;Davis, Mark M.
通讯作者：
Davis, Mark M.
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
15.9
作者：
Cui, Yue;Franciszkiewicz, Katarzyna;Lantz, Olivier
通讯作者：
Lantz, Olivier
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob