Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways.
Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways.
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肿瘤浸润淋巴细胞的不同亚群以不同方式与鼻咽癌进展相关
DOI：
10.1186/1476-4598-9-4
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发表时间：
2010-01-10
期刊：
影响因子：
37.3
通讯作者：
Zeng YX
中科院分区：
文献类型：
--
作者：
Zhang YL;Li J;Mo HY;Qiu F;Zheng LM;Qian CN;Zeng YX
背景越来越多的证据表明肿瘤浸润淋巴细胞（tumor infiltrating lymphocytes，TIL）与肿瘤患者的预后有关。本研究旨在探讨肿瘤浸润细胞毒性T淋巴细胞（CTL）、活化CTL、调节性T淋巴细胞（Treg）和Th 17淋巴细胞的密度与鼻咽癌（NPC）患者预后及临床病理特征的关系。通过Kaplan-Meier分析和考克斯回归评估浸润淋巴细胞密度的预后价值。CD 8 + TIL密度与淋巴结转移呈正相关（P <0.05），Foxp 3 +TIL密度与T分期呈负相关（P < 0.05）。对于生存评估，Foxp 3 +TIL或Foxp 3 +TIL联合GrB+TIL的密度与所有患者和晚期疾病患者（III期和IV期，P < 0.01）的总生存期（OS）和无进展生存期（PFS）相关（P <0.01）。早期患者CD 8 +TIL低密度或FOXP 3 +TIL/CD 8 +TIL比值高与PFS较好相关（I期和II期，P < 0.05）。IL-17+TIL与NPC患者的临床病理特征及生存期无显著相关性。结论本研究首次发现肿瘤浸润Foxp 3 +TIL是影响NPC患者预后的独立有利因素，尤其是对晚期疾病患者。
BackgroundIncreasing amounts of evidence indicate that tumor infiltrating lymphocytes (TIL) are correlated with the prognosis of cancer patients. This study focuses on the association between the densities of tumor infiltrating cytotoxic T lymphocytes (CTL), activated CTL, regulatory T lymphocytes (Treg) and Th17 lymphocytes, and the prognosis and clinicopathological features of nasopharyngeal carcinoma (NPC) patients.ResultsDouble immunohistochemical staining was performed in 106 biopsy specimens from newly diagnosed NPC patients. Prognostic values of infiltrating lymphocyte densities were evaluated by Kaplan-Meier analysis and Cox regression. The density of CD8+ TIL was positively correlated with lymph node metastasis, while the density of Foxp3+TIL was negatively associated with T stage (P < 0.05). For survival evaluation, the density of Foxp3+TIL or Foxp3+TIL combined with GrB+TIL together was associated with better overall survival (OS) and progression-free survival (PFS) (P < 0.01) in all patients and in the patients with late-stage diseases (Stages III and IV, P < 0.01). Meanwhile a low density of CD8+TIL or high ratio of FOXP3+TIL to CD8+TIL was correlated with better PFS in early stage patients (Stages I and II, P < 0.05). No significant association was found between IL-17+TIL and clinicopathological characteristic or survival of NPC patients.ConclusionsOur study identifies for the first time the tumor infiltrating Foxp3+TIL as an independent favorable factor in the prognosis of NPC patients, especially for the patients with late-stage diseases.
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影响因子：
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