MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1.
MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1.
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MicroRNA-33b 通过靶向 HMGA2、SALL4 和 Twist1 抑制乳腺癌转移
DOI：
10.1038/srep09995
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发表时间：
2015-04-28
影响因子：
4.6
通讯作者：
Ouyang G
中科院分区：
文献类型：
--
作者：
Lin Y;Liu AY;Fan C;Zheng H;Li Y;Zhang C;Wu S;Yu D;Huang Z;Liu F;Luo Q;Yang CJ;Ouyang G
MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target mRNAs. Current evidence indicates that miR-33b is involved in the regulation of lipid metabolism, cholesterol homeostasis, glucose metabolism and several human diseases; however, whether miR-33b contributes to the pathogenesis of human cancers and participates in the regulation of self-renewal of human cancer stem cells remains unknown. Here, we report the identification of miR-33b as a negative regulator of cell stemness and metastasis in breast cancer. Compared with paired normal breast tissues, miR-33b expression is downregulated in breast tumor samples and is inversely correlated with lymph node metastatic status. Ectopic overexpression of miR-33b in highly metastatic breast cancer cells suppresses cell self-renewal, migration and invasionin vitroand inhibits lung metastasisin vivo. Conversely, miR-33b knockdown promotes the self-renewal, migration and invasion capabilities of noncancerous mammary epithelial cells. The mechanism through which miR-33b inhibits the stemness, migration and invasion of breast cancer cells is by targeting HMGA2, SALL4 and Twist1. These data indicate that miR-33b acts as an onco-suppressive microRNA in breast cancer progression by inhibiting the stemness and metastasis of breast cancer cells.
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影响因子：
10.5
作者：
Dontu, G;Abdallah, WM;Wicha, MS
通讯作者：
Wicha, MS
DOI：
10.1002/hep.26159
发表时间：
2013-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Oikawa T;Kamiya A;Zeniya M;Chikada H;Hyuck AD;Yamazaki Y;Wauthier E;Tajiri H;Miller LD;Wang XW;Reid LM;Nakauchi H
通讯作者：
Nakauchi H
影响因子：
21.3
作者：
Pencheva N;Tavazoie SF
通讯作者：
Tavazoie SF
Twist2通过促进上皮-间质转化和癌症干细胞样细胞自我更新促进乳腺癌进展
影响因子：
8
作者：
Fang, X.;Cai, Y.;Ouyang, G.
通讯作者：
Ouyang, G.
影响因子：
50.3
作者：
Fedele, Monica;Visone, Rosa;Fusco, Alfredo
通讯作者：
Fusco, Alfredo