Tumor necrosis factor-α, lymphotoxin-α, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting
Tumor necrosis factor-α, lymphotoxin-α, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting
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肿瘤坏死因子-α、淋巴毒素-α、白介素-10基因多态性与冠状动脉支架术后再狭窄
DOI：
10.1016/j.cyto.2003.08.004
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发表时间：
2003
期刊：
影响因子：
3.8
通讯作者：
A. Kastrati
中科院分区：
文献类型：
--
作者：
W. Koch;K. Tiroch;N. Beckerath;A. Schömig;A. Kastrati
炎症是冠状动脉支架置入引起的血管壁损伤的主要反应。细胞因子肿瘤坏死因子 (TNF)-α、淋巴毒素 (LT)-α 和白介素 (IL)-10 与炎症反应密切相关。炎症过程的强度以及支架植入后的血管造影或临床结果受到遗传因素的影响。我们研究了编码TNF-α（-863C/A、-308G/A）、LT-α（252G/A）和IL-10（-1082G/A、-819C/T和-592C/A）的基因的单核苷酸多态性与冠状动脉支架置入术后再狭窄、死亡或心肌梗死（MI）的发生率相关的可能性。已知基因变异与转录活性和/或蛋白质产生相关。我们的研究连续纳入了 1850 名患有症状性冠状动脉疾病并接受支架植入术的患者。干预后六个月对 1556 名患者（84.1%）进行了随访血管造影。我们发现多态性与再狭窄、死亡或心肌梗死无关。此外，我们没有观察到多态性特异性单倍型与不良血管造影和临床结果之间的关系。总之，TNF-α、LT-α 和 IL-10 基因的功能相关多态性并不代表表明冠状动脉支架置入术后再狭窄、死亡或 MI 风险的遗传标记。
Inflammation is the primary response to vessel wall injury caused by stent placement in coronary arteries. The cytokines tumor necrosis factor (TNF)-α, lymphotoxin (LT)-α, and interleukin (IL)-10 are critically involved in inflammatory reactions. The intensity of the inflammatory process and the angiographic or clinical outcome after stenting are influenced by genetic factors. We investigated the possibility that single nucleotide polymorphisms of the genes encoding TNF-α (−863C/A, −308G/A), LT-α (252G/A), and IL-10 (−1082G/A, −819C/T, and −592C/A) are associated with the incidence of restenosis, death, or myocardial infarction (MI) after coronary stenting. The gene variations are known to be correlated with transcriptional activity and/or protein production. Our study included 1850 consecutive patients with symptomatic coronary artery disease who underwent stent implantation. Follow-up angiography was performed in 1556 patients (84.1%) at six months after the intervention. We found that the polymorphisms are not associated with restenosis, death, or MI. In addition, we did not observe a relationship between polymorphism-specific haplotypes and adverse angiographic and clinical outcomes. In conclusion, functionally relevant polymorphisms of the genes for TNF-α, LT-α, and IL-10 do not represent genetic markers indicating the risk of restenosis, death, or MI after coronary stenting.
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DOI：
--
发表时间：
1995
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
K. Roebuck;A. Rahman;V. Lakshminarayanan;K. Janakidevi;A. B. Malik
通讯作者：
K. Roebuck;A. Rahman;V. Lakshminarayanan;K. Janakidevi;A. B. Malik
IL-10 对中性粒细胞衍生趋化因子表达的调节。
DOI：
--
发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kasama,T;Strieter,RM;Lukacs,NW;Burdick,MD;Kunkel,SL
通讯作者：
Kunkel,SL
影响因子：
4.4
作者：
A. Chernoff;E. Granowitz;L. Shapiro;E. Vannier;G. Lonnemann;J. Angel;J. Kennedy;A. Rabson;S. Wolff;C. Dinarello
通讯作者：
A. Chernoff;E. Granowitz;L. Shapiro;E. Vannier;G. Lonnemann;J. Angel;J. Kennedy;A. Rabson;S. Wolff;C. Dinarello
DOI：
10.1073/pnas.95.17.10134
发表时间：
1998-08-18
影响因子：
11.1
作者：
Rogers, C;Edelman, ER;Simon, DI
通讯作者：
Simon, DI
DOI：
10.1164/ajrccm.156.4.12tac-14
发表时间：
1997-10-01
影响因子：
24.7
作者：
Rosenwasser, LJ;Borish, L
通讯作者：
Borish, L