Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.
Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.
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DOI：
10.1016/j.cub.2018.06.070
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发表时间：
2018-09-24
期刊：
影响因子：
--
通讯作者：
Hunt PA
中科院分区：
文献类型：
--
作者：
Horan TS;Pulcastro H;Lawson C;Gerona R;Martin S;Gieske MC;Sartain CV;Hunt PA
20年前，意外接触双酚A(BPA)导致对照组小鼠的染色体异常卵子突然增加[1]。随后的啮齿动物研究表明，暴露对成年健康和生育力有影响的发育影响(例如，[2-9]；在[10-17]中回顾)。对猴子、人类、鱼类和蠕虫的研究表明，双酚A的影响跨物种扩展(例如，[18-30]；在[31-33]中回顾)。广泛使用已导致无处不在的环境污染和人类接触双酚A。消费者的担忧导致了使用结构相似的双酚生产的“不含双酚”产品，这些双酚现在是可检测到的环境和人类污染物(例如，[34-41])。我们在此报告了由减数分裂变化引发的研究，反映了我们以前的双酚A经验，并涉及到从受损的聚砜笼子中暴露于BPS(一种常见的双酚A替代品)。与双酚A[1，2，5]一样，我们的数据显示，暴露于常见的替代双酚会在两性中诱导生殖系效应，这可能会影响多代人。这些发现增加了这类化学品构成生物风险的越来越多的证据。快速生产BPA和其他EDCs的结构变体绕过了消除危险化学品的努力，加剧了安全评估的监管负担，并增加了环境污染。我们的经验表明，这些环境污染物不仅对生殖健康而且对研究环境的完整性构成风险。内分泌细胞就像内源性激素一样，可以影响不同的过程。生殖系的敏感性使我们能够检测到一些效应，尽管这些效应在其他系统中并不立即显现，但可能会导致破坏实验重复性和阻碍科学进步的变异性。
20 years ago, accidental bisphenol A (BPA) exposure caused a sudden increase in chromosomally abnormal eggs from our control mice [1]. Subsequent rodent studies demonstrated developmental effects of exposure with repercussions on adult health and fertility (e.g., [2–9]; reviewed in [10–17]). Studies in monkeys, humans, fish, and worms suggest BPA effects extend across species (e.g., [18–30]; reviewed in [31–33]). Widespread use has resulted in ubiquitous environmental contamination and human BPA exposure. Consumer concern resulted in "BPA-free" products produced using structurally similar bisphenols that are now detectable environmental and human contaminants (e.g., [34–41]). We report here studies initiated by meiotic changes mirroring our previous BPA experience and implicating exposure to BPS (a common BPA replacement) from damaged polysulfone cages. Like with BPA [1, 2, 5], our data show that exposure to common replacement bisphenols induces germline effects in both sexes that may affect multiple generations. These findings add to growing evidence of the biological risks posed by this class of chemicals. Rapid production of structural variants of BPA and other EDCs circumvents efforts to eliminate dangerous chemicals, exacerbates the regulatory burden of safety assessment, and increases environmental contamination. Our experience suggests that these environmental contaminants pose a risk not only to reproductive health but also to the integrity of the research environment. EDCs, like endogenous hormones, can affect diverse processes. The sensitivity of the germline allows us to detect effects that, although not immediately apparent in other systems, may induce variability that undermines experimental reproducibility and impedes scientific advancement.
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影响因子：
3.4
作者：
Elsworth, John D.;Jentsch, J. David;VandeVoort, Catherine A.;Roth, Robert H.;Redmond, D. Eugene, Jr.;Leranth, Csaba
通讯作者：
Leranth, Csaba
影响因子：
11.4
作者：
Ji, Kyunghee;Hong, Seongjin;Choi, Kyungho
通讯作者：
Choi, Kyungho
DOI：
10.1073/pnas.1207854109
发表时间：
2012-10-23
影响因子：
11.1
作者：
Hunt, Patricia A.;Lawson, Crystal;VandeVoort, Catherine A.
通讯作者：
VandeVoort, Catherine A.
影响因子：
3.8
作者：
Albert, Oceane;Nardelli, Thomas C.;Robaire, Bernard
通讯作者：
Robaire, Bernard
影响因子：
3.7
作者：
Eladak, Soria;Moison, Delphine;Habert, Rene
通讯作者：
Habert, Rene