The Effect of Diet on Improved Endurance in Male C57BL/6 Mice.
The Effect of Diet on Improved Endurance in Male C57BL/6 Mice.
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DOI：
10.3390/nu10081101
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发表时间：
2018-08-16
期刊：
影响因子：
5.9
通讯作者：
Kindy MS
中科院分区：
文献类型：
--
作者：
Yu J;Zhu H;Taheri S;Perry S;Kindy MS
食用水果和蔬菜似乎有助于保持足够的运动水平并提高耐力。然而，这一过程中涉及的机制尚不清楚。在当前的研究中，在小鼠模型中研究了富含水果和蔬菜的饮食 (GrandFusion®) 对运动耐力的影响。 GrandFusion (GF) 饮食增加了线粒体 DNA 和酶活性，同时还刺激体内线粒体 mRNA 合成。 GF饮食增加了参与线粒体生物发生的因子的mRNA表达，包括过氧化物酶体增殖物激活受体γ共激活剂1α（PGC-1α）、线粒体转录因子A（Tfam）、雌激素相关受体α（ERRα）、核呼吸因子1（NRF-1）、细胞色素c氧化酶IV（COXIV）和ATP合成酶（ATPsyn）。与常规饮食的对照组相比，接受 GF 饮食治疗的小鼠的跑步耐力、转棒毅力和握力都有所提高。此外，GF饮食增加了磷酸化AMP激活蛋白激酶（AMPK）、sirtuin 1（SIRT1）、PGC-1α和过氧化物酶体增殖物激活受体δ（PPAR-δ）的蛋白表达，这一变化大于运动相关的变化。最后，GF 降低磷酸化核糖体蛋白 S6 激酶 1 (p-S6K1) 的表达并减少自噬。这些结果表明，GF 饮食可以增强运动耐力，这是通过线粒体生物发生和功能介导的。
The consumption of fruits and vegetables appears to help with maintaining an adequate level of exercise and improves endurance. However, the mechanisms that are involved in this process are not well understood. In the current study, the impact of diets enriched in fruits and vegetables (GrandFusion®) on exercise endurance was examined in a mouse model. GrandFusion (GF) diets increased mitochondrial DNA and enzyme activity, while they also stimulated mitochondrial mRNA synthesis in vivo. GF diets increased both the mRNA expression of factors involved in mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), mitochondrial transcription factor A (Tfam), estrogen-related receptor alpha (ERRα), nuclear respiratory factor 1 (NRF-1), cytochrome c oxidase IV (COXIV) and ATP synthase (ATPsyn). Mice treated with GF diets showed an increase in running endurance, rotarod perseverance and grip strength when compared to controls who were on a regular diet. In addition, GF diets increased the protein expression of phosphorylated AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), PGC-1α and peroxisome proliferator-activated receptor delta (PPAR-δ), which was greater than exercise-related changes. Finally, GF reduced the expression of phosphorylated ribosomal protein S6 kinase 1 (p-S6K1) and decreased autophagy. These results demonstrate that GF diets enhance exercise endurance, which is mediated via mitochondrial biogenesis and function.
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影响因子：
9.8
作者：
Wang YX;Zhang CL;Yu RT;Cho HK;Nelson MC;Bayuga-Ocampo CR;Ham J;Kang H;Evans RM
通讯作者：
Evans RM
DOI：
10.1093/gerona/61.6.534
发表时间：
2006-06-01
影响因子：
5.1
作者：
Menshikova, Elizabeth V.;Ritov, Vladimir B.;Goodpaster, Bret H.
通讯作者：
Goodpaster, Bret H.
影响因子：
64.5
作者：
Ruas JL;White JP;Rao RR;Kleiner S;Brannan KT;Harrison BC;Greene NP;Wu J;Estall JL;Irving BA;Lanza IR;Rasbach KA;Okutsu M;Nair KS;Yan Z;Leinwand LA;Spiegelman BM
通讯作者：
Spiegelman BM
PGC-1α 促进运动诱导的小鼠骨骼肌自噬
影响因子：
2.5
作者：
Halling, Jens F.;Ringholm, Stine;Pilegaard, Henriette
通讯作者：
Pilegaard, Henriette
影响因子：
--
作者：
Talbot, Jared;Maves, Lisa
通讯作者：
Maves, Lisa