Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation.
Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation.
复制标题
低频磁场对黑色素瘤的影响：肿瘤抑制和免疫调节。
DOI：
10.1186/1471-2407-13-582
复制
发表时间：
2013-12-06
期刊：
影响因子：
3.8
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Nie Y;Du L;Mou Y;Xu Z;Weng L;Du Y;Zhu Y;Hou Y;Wang T
We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here investigated whether LF-MF can inhibit the proliferation and metastasis of melanoma and influence immune function. The effect of MF on the proliferation, cell cycle and ultrastracture of B16-F10 in vitro was detected by cell counting Kit-8 assay, flow cytometry, and transmission electron microscopy. Lung metastasis mice were prepared by injection of 2 × 105 B16-F10 melanoma cells into the tail vein in C57BL/6 mice. The mice were then exposed to an LF-MF (0.4 T, 7.5 Hz) for 43 days. Survival rate, tumor markers and the innate and adaptive immune parameters were measured. The growth of B16-F10 cells was inhibited after exposure to the LF-MF. The inhibition was related to induction of cell cycle arrest and decomposition of chromatins. Moreover, the LF-MF prolonged the mouse survival rate and inhibited the proliferation of B16-F10 in melanoma metastasis mice model. Furthermore, the LF-MF modulated the immune response via regulation of immune cells and cytokine production. In addition, the number of Treg cells was decreased in mice with the LF-MF exposure, while the numbers of T cells as well as dendritic cells were significantly increased. LF-MF inhibited the growth and metastasis of melanoma cancer cells and improved immune function of tumor-bearing mice. This suggests that the inhibition may be attributed to modulation of LF-MF on immune function and LF-MF may be a potential therapy for treatment of melanoma.
登录
查看更多内容
影响因子：
4
作者：
Frahm, Jana;Lantow, Magareta;Simko, Myrtill
通讯作者：
Simko, Myrtill
影响因子：
5.8
作者：
Arenberg, DA;White, ES;Strieter, RM
通讯作者：
Strieter, RM
影响因子：
1.9
作者：
Tofani, S;Barone, D;Ronchetto, F
通讯作者：
Ronchetto, F
影响因子：
2.6
作者：
Koh, Eui Kwan;Ryu, Byung-Kyu;Chae, Kwon-Seok
通讯作者：
Chae, Kwon-Seok
影响因子：
3.7
作者：
Teodori, L;Albertini, MC;Accorsi, A
通讯作者：
Accorsi, A