Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI.
Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI.
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DOI：
10.1002/mrm.22547
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发表时间：
2010-11
影响因子：
3.3
通讯作者：
Omens JH
中科院分区：
文献类型：
--
作者：
Chuang JS;Zemljic-Harpf A;Ross RS;Frank LR;McCulloch AD;Omens JH
一种用于计算小鼠三维 (3D) 心壁应变分布的基于模型的方法已经开发出来，并在扩张型心肌病基因工程小鼠模型中进行了测试。来自 MR 标记和谐波相位 (HARP) 跟踪的数据用于测量材料点位移，并使用可变形参数模型计算整个左心室 (LV) 的 3D 拉格朗日应变。将心肌细胞专门缺乏纽蛋白（VclKO）的小鼠模型与野生型（WT）同窝小鼠进行比较。 3D 应变分析揭示了 WT 和 VclKO 小鼠在 8 周龄时收缩功能刚刚开始下降时的左室壁力学差异。最值得注意的是，VclKO 心脏的收缩末期径向应变和扭转剪切减少，导致区域机械功能障碍。这项研究证明了使用 MRI 标记方法检测心血管疾病基因工程小鼠模型中 3D 心肌应变分布变化的可行性。
A model-based method for calculating three-dimensional (3D) cardiac wall strain distributions in the mouse has been developed and tested in a genetically engineered mouse model of dilated cardiomyopathy. Data from MR tagging and harmonic phase (HARP) tracking were used to measure material point displacements, and 3D Lagrangian strains were calculated throughout the entire left ventricle (LV) with a deformable parametric model. A mouse model where cardiomyocytes are specifically made deficient in vinculin (VclKO) were compared to wild-type (WT) littermates. 3D strain analysis revealed differences in LV wall mechanics between WT and VclKO mice at 8 weeks of age when systolic function had just begun to decline. Most notably, end-systolic radial strain and torsional shear were reduced in VclKO hearts which contributed to regional mechanical dysfunction. This study demonstrates the feasibility of using MRI tagging methods to detect alterations in 3D myocardial strain distributions in genetically engineered mouse models of cardiovascular disease.
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影响因子：
20.1
作者：
Kubota, T;McTiernan, CF;Feldman, AM
通讯作者：
Feldman, AM
影响因子：
19.7
作者：
Moore, CC;Lugo-Olivieri, CH;Zerhouni, EA
通讯作者：
Zerhouni, EA
影响因子：
3.3
作者：
Kuijer, JPA;Jansen, E;Heethaar, RM
通讯作者：
Heethaar, RM
DOI：
10.1152/ajpheart.01016.2005
发表时间：
2006-11-01
影响因子：
4.8
作者：
Liu, Wei;Ashford, Marvin W.;Yu, Xin
通讯作者：
Yu, Xin
影响因子：
2.4
作者：
MCCULLOCH, AD;OMENS, JH
通讯作者：
OMENS, JH