Prototypes virus of hand, foot and mouth disease infections and severe cases in Gansu, China: a spatial and temporal analysis.
Prototypes virus of hand, foot and mouth disease infections and severe cases in Gansu, China: a spatial and temporal analysis.
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甘肃省手足口病感染和重症病例的原型病毒时空分析
DOI：
10.1186/s12879-022-07393-4
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发表时间：
2022-04-26
影响因子：
3.7
通讯作者：
Hu, Wenbiao
中科院分区：
文献类型：
--
作者：
Liu, Haixia;Zhang, Yuzhou;Zhang, Hong;Zheng, Yunhe;Gou, Faxiang;Yang, Xiaoting;Cheng, Yao;McClymont, Hannah;Li, Hui;Liu, Xinfeng;Hu, Wenbiao
手足口病（手足口病）重症病例与肠道病毒感染的时空关系研究较少。本研究旨在调查甘肃省手足口病的流行特征和发病率的空间聚集性，探讨肠病毒71型（EV71）和柯萨奇病毒A16型（CoxA16）与手足口病重症病例的关系。从中国传染病信息系统（CIDIS）收集2018年1月1日至12月31日期间的每周手足口病县特定数据，包括中国甘肃省肠道病毒类型（EV71和CoxA16），严重和非严重病例。采用时间风险[频率指数（α）、持续时间指数（β）和强度指数（γ）]和空间聚类分析方法评价手足口病流行特征，确定手足口病高发地区。采用时间序列互相关函数和回归模型探讨两种病毒（EV71/Cox16）比值（EC）与手足口病重症指数（即重症/非重症）（SI）的关系。甘肃省定西市部分县被确定为时间风险指数的热点地区。时间序列交叉相关分析显示，SI与EC在4周的时间滞后上显著相关（r = 0.417, P < 0.05）。回归分析显示，SI与EC呈正相关（β = 0.04, 95%可信区间（CI） 0.02 ~ 0.06）。手足口病发病的空间格局与肠道病毒有关。该研究表明，EC可被视为预测甘肃省严重手足口病病例的潜在预警信号。
Little research has been conducted on the spatio-temporal relationship between the severe cases and the enteroviruses infections of hand, foot and mouth disease (HFMD). This study aimed to investigate epidemic features and spatial clusters of HFMD incidence rates and assess the relationship between Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) and severe cases of HMFD in Gansu province, China. Weekly county-specific data on HFMD between 1st January and 31st December 2018 were collected from the China Infectious Disease Information System (CIDIS), including enterovirus type (EV71 and CoxA16), severe and non-severe cases in Gansu province, China. Temporal risk [frequency index (α), duration index (β) and intensity index (γ)] and spatial cluster analysis were used to assess epidemic features and identify high-risk areas for HFMD. Time-series cross-correlation function and regression model were used to explore the relationship between the ratios of two types of viruses (i.e. EV71/Cox16) (EC) and severe cases index (i.e. severe cases/non-severe cases) (SI) of HFMD. Some counties in Dingxi City, Gansu were identified as a hot spot for the temporal risk indices. Time-series cross-correlation analysis showed that SI was significantly associated with EC (r = 0.417, P < 0.05) over a 4-week time lag. The regression analysis showed that SI was positively associated with EC (β = 0.04, 95% confidence interval (CI) 0.02–0.06). The spatial patterns of HFMD incidence were associated with enteroviruses in Gansu. The research suggested that the EC could be considered a potential early warning sign for predicting severe cases of HFMD in Gansu province.
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影响因子：
3.7
作者：
Kim, Bongyoung;Moon, Shinje;Oh, Sung Hee
通讯作者：
Oh, Sung Hee
影响因子：
5.5
作者：
Jiang, Lina;Wang, Jing;Ning, Chuanyi
通讯作者：
Ning, Chuanyi
影响因子：
8
作者：
Chen, Kow-Tong;Chang, Hsiao-Ling;Yang, Jyh-Yuan
通讯作者：
Yang, Jyh-Yuan
DOI：
10.15585/mmwr.mm6429a8
发表时间：
2015-07-31
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Buttery VW;Kenyon C;Grunewald S;Oberste MS;Nix WA
通讯作者：
Nix WA
影响因子：
2.1
作者：
Khazaei, Salman;Soheilyzad, Mokhtar;Khazaei, Somayeh
通讯作者：
Khazaei, Somayeh