Integration of gray matter nodules into functional cortical circuits in periventricular heterotopia.
Integration of gray matter nodules into functional cortical circuits in periventricular heterotopia.
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DOI：
10.1016/j.yebeh.2013.08.028
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Chang BS
中科院分区：
文献类型：
--
作者：
Christodoulou JA;Barnard ME;Del Tufo SN;Katzir T;Whitfield-Gabrieli S;Gabrieli JD;Chang BS
神经元回路的改变被认为是包括癫痫在内的许多神经疾病的重要底物。脑室周围结节异位症(PNH)的发育性脑畸形患者通常既有癫痫发作又有阅读障碍，有证据表明异常的神经元连接是这两个临床特征的基础。我们使用基于任务的功能磁共振成像(FMRI)来确定这种情况下的异位灰质结节是否整合到功能皮质回路中。在阅读相关任务的执行过程中，8名PNH参与者获得了血氧水平依赖(BOLD)功能磁共振成像。确定了异位灰质内神经激活的证据，然后系统地绘制了皮质共同激活的区域图。研究结果与静息状态的功能连接结果和fMRI阅读相关任务的表现相关。6名参与者(75%)至少在灰质异位的一个区域内表现出激活。直接覆盖异位的皮质区域通常是共激活的(60%)，在无任务休息状态下，已知与异位有功能连接的区域(73%)。七个主要任务中有六个(86%)的对比导致至少一个参与者的异位激活。在视觉刺激的快速命名过程中最常见的是激活，这是该患者群体中的一种特征损害。我们的发现代表了一个系统的证明，在与癫痫和阅读障碍相关的神经元迁移障碍中，异位灰质可以被代谢共激活。灰质结节最常与解剖上覆盖的皮质和其他与异位有静息状态连接的区域共同激活。这些结果对于理解癫痫和阅读障碍的网络发病机制具有更广泛的意义。
Alterations in neuronal circuitry are recognized as an important substrate of many neurological disorders, including epilepsy. Patients with the developmental brain malformation of periventricular nodular heterotopia (PNH) often have both seizures and dyslexia, and there is evidence to suggest that aberrant neuronal connectivity underlies both of these clinical features. We used task-based functional MRI (fMRI) to determine whether heterotopic nodules of gray matter in this condition are integrated into functional cortical circuits. Blood oxygenation level-dependent (BOLD) fMRI was acquired in eight participants with PNH during the performance of reading-related tasks. Evidence of neural activation within heterotopic gray matter was identified, and regions of cortical co-activation were then mapped systematically. Findings were correlated with resting-state functional connectivity results and with performance on the fMRI reading-related tasks. Six participants (75%) demonstrated activation within at least one region of gray matter heterotopia. Cortical areas directly overlying the heterotopia were usually co-activated (60%), as were areas known to have functional connectivity to the heterotopia in the task-free resting state (73%). Six of seven (86%) primary task contrasts resulted in heterotopia activation in at least one participant. Activation was most commonly seen during rapid naming of visual stimuli, a characteristic impairment in this patient population. Our findings represent a systematic demonstration that heterotopic gray matter can be metabolically coactivated in a neuronal migration disorder associated with epilepsy and dyslexia. Gray matter nodules were most commonly coactivated with anatomically overlying cortex and other regions with resting-state connectivity to heterotopia. These results have broader implications for understanding the network pathogenesis of both seizures and reading disabilities.
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3.5
作者：
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通讯作者：
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