Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model.
Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model.
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DOI：
10.1186/s10194-022-01384-1
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发表时间：
2022-01-21
期刊：
影响因子：
--
通讯作者：
Yen JC
中科院分区：
文献类型：
--
作者：
Liu TT;Morais A;Takizawa T;Mulder I;Simon BJ;Chen SP;Wang SJ;Ayata C;Yen JC
非侵入性迷走神经刺激（nVNS）最近成为一种有前途的治疗偏头痛。我们以前证明，迷走神经刺激抑制皮层扩散性抑制（CSD），偏头痛先兆和触发头痛的电生理事件，但是，最佳nVNS范式尚未确定。在经验证的大鼠模型中，测试了不同强度和剂量的nVNS以改善对KCl诱发的CSD频率和CSD的电阈值的功效。通过每日nVNS递送持续四周来评价慢性疗效。我们还通过蛋白质印迹和免疫组化检查了nVNS对神经炎症和三叉神经血管激活的影响。nVNS以强度依赖性方式抑制对CSD的易感性。两个2分钟的nVNS间隔5分钟提供了最高的电CSD阈值和KCl诱发的CSD的频率的功效。持续四周的每日nVNS与CSD前20分钟的单次nVNS相比没有进一步增强疗效。最佳nVNS还减弱CSD诱导的皮质环氧合酶-2、三叉神经节中降钙素基因相关肽和三叉神经尾侧核中c-Fos表达的上调。我们的研究提供了关于抑制CSD的最佳nVNS参数的见解，并表明其在偏头痛治疗中对CSD诱导的神经炎症和三叉神经血管激活的益处。在线版本包含补充材料，可通过10.1186/s10194-022-01384-1获得。
Noninvasive vagus nerve stimulation (nVNS) has recently emerged as a promising therapy for migraine. We previously demonstrated that vagus nerve stimulation inhibits cortical spreading depression (CSD), the electrophysiological event underlying migraine aura and triggering headache; however, the optimal nVNS paradigm has not been defined. Various intensities and doses of nVNS were tested to improve efficacy on KCl-evoked CSD frequency and electrical threshold of CSD in a validated rat model. Chronic efficacy was evaluated by daily nVNS delivery for four weeks. We also examined the effects of nVNS on neuroinflammation and trigeminovascular activation by western blot and immunohistochemistry. nVNS suppressed susceptibility to CSD in an intensity-dependent manner. Two 2-minute nVNS 5 min apart afforded the highest efficacy on electrical CSD threshold and frequency of KCl-evoked CSD. Daily nVNS for four weeks did not further enhance efficacy over a single nVNS 20 min prior to CSD. The optimal nVNS also attenuated CSD-induced upregulation of cortical cyclooxygenase-2, calcitonin gene-related peptide in trigeminal ganglia, and c-Fos expression in trigeminal nucleus caudalis. Our study provides insight on optimal nVNS parameters to suppress CSD and suggests its benefit on CSD-induced neuroinflammation and trigeminovascular activation in migraine treatment. The online version contains supplementary material available at 10.1186/s10194-022-01384-1.
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DOI：
10.1186/1129-2377-14-62
发表时间：
2013-07-23
期刊：
The journal of headache and pain
影响因子：
--
作者：
Costa C;Tozzi A;Rainero I;Cupini LM;Calabresi P;Ayata C;Sarchielli P
通讯作者：
Sarchielli P
DOI：
10.1124/jpet.111.188953
发表时间：
2012-05-01
影响因子：
3.5
作者：
Furmaga, Havan;Sadhu, Mohona;Frazer, Alan
通讯作者：
Frazer, Alan
影响因子：
4.9
作者：
Goadsby, P. J.;Grosberg, B. M.;Simmons, K. A.
通讯作者：
Simmons, K. A.
DOI：
10.1124/jpet.106.104166
发表时间：
2006-08-01
影响因子：
3.5
作者：
Dorr, Adrienne E.;Debonnel, Guy
通讯作者：
Debonnel, Guy
影响因子：
2.5
作者：
Groves, DA;Bowman, EM;Brown, VJ
通讯作者：
Brown, VJ