Racial differences in gene-specific DNA methylation levels are present at birth.
Racial differences in gene-specific DNA methylation levels are present at birth.
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DOI：
10.1002/bdra.20770
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发表时间：
2011-08
影响因子：
--
通讯作者：
Thomas, Fridtjof
中科院分区：
文献类型：
--
作者：
Adkins, Ronald M.;Krushkal, Julia;Tylavsky, Frances A.;Thomas, Fridtjof
DNA 甲基化模式在儿童和成人之间存在差异，并且在多种疾病过程中发挥着明确的作用，尤其是癌症。这些差异的起源尚不清楚，这是一个与儿童和成人癌症具体相关的问题。对 201 名新生儿（107 名非裔美国人和 94 名白种人）的 26,485 个常染色体 CpG 的 DNA 甲基化水平进行了测定。进行非参数分析来检查这些甲基化水平与产次、母亲年龄、新生儿胎龄、新生儿性别和新生儿种族之间的关系。为了确定混杂因素的可能影响，还通过第二个和第三个变量进行了分层。对于含有种族间 DNA 甲基化水平显着差异的 CpG 的基因，进行分析以确定高度代表性的基因本体术语和功能途径。 13.7% (3,623) 的常染色体 CpG 在非裔美国人和白种人之间表现出显着不同的 DNA 甲基化水平。 2% 的常染色体 CpG 在男性和女性新生儿之间具有显着不同的 DNA 甲基化水平。癌症途径，包括四种癌症（胰腺癌、前列腺癌、膀胱癌和黑色素瘤），在种族之间的发病率存在显着差异，在含有显着种族差异 CpG 的基因中具有高度代表性。出生时，非裔美国人和白种人之间的 CpG 二核苷酸子集的 DNA 甲基化水平存在显着差异。一些癌症的表观遗传前兆可能在出生时就存在，这些差异部分解释了种族之间特定癌症的不同发病率。
DNA methylation patterns differ among children and adults and play an unambiguous role in several disease processes, particularly cancers. The origin of these differences are inadequately understood, and this is a question of specific relevance to childhood and adult cancer. DNA methylation levels at 26,485 autosomal CpGs were assayed in 201 newborns (107 African-American and 94 Caucasian). Nonparametric analyses were performed to examine the relation between these methylation levels and maternal parity, maternal age, newborn gestational age, newborn gender,and newborn race. To identify the possible influences of confounding, stratification was additionally performed by a second and third variable. For genes containing CpGs with significant differences in DNA methylation levels between races, analyses were performed to identify highly represented gene ontological terms and functional pathways. 13.7% (3,623) of the autosomal CpGs exhibited significantly different levels of DNA methylation between African-Americans and Caucasians. 2% of autosomal CpGs had significantly different DNA methylation levels between male and female newborns. Cancer pathways, including four (pancreatic, prostate, bladder, and melanoma) with substantial differences in incidence between the races, were highly represented among the genes containing significant race-divergent CpGs. At birth, there are significantly different DNA methylation levels between African-Americans and Caucasians at a subset of CpG dinucleotides. It is possible that some of the epigenetic precursors to cancer exist at birth and that these differences partially explain the different incidence rates of specific cancers between the races.
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影响因子：
3.7
作者：
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通讯作者：
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作者：
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通讯作者：
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