Cervical disc degeneration is associated with a reduction in mobility: A cross-sectional study of 1211 asymptomatic healthy subjects
Cervical disc degeneration is associated with a reduction in mobility: A cross-sectional study of 1211 asymptomatic healthy subjects
复制标题
颈椎间盘退变与活动能力下降相关：对 1211 名无症状健康受试者的横断面研究
DOI：
10.1016/j.jocn.2022.03.035
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发表时间：
2022
影响因子：
2
通讯作者：
Imagama Shiro
中科院分区：
文献类型：
--
作者：
Machino Masaaki;Nakashima Hiroaki;Ito Keigo;Ando Kei;Ito Sadayuki;Kato Fumihiko;Imagama Shiro
本研究的目的是利用磁共振成像（MRI）建立颈椎间盘退变的年龄相关变化和性别差异，并评估无症状受试者颈椎间盘退变严重程度与活动度之间的相关性。共有1，211名相对健康的志愿者（606名男性和605名女性，平均年龄49.5岁）接受了MRI检查，没有神经系统症状。在20岁到70岁之间的每十年中，至少有100名男性和100名女性被纳入其中。这项研究是一个更大的项目的一部分，并使用了一些以前发表的数据。根据改良Pfirrmann分类系统定义颈椎间盘退变。通过C2/C3至C7/T1的个体Pfirrmann评分的总和计算椎间盘退变总评分（DDS）。颈椎活动度（ROM）通过X线片测量。总DDS随着年龄的增长而逐渐增加。在所有十年中，女性的DDS均低于男性。在40多岁或更大年龄组中，超过一半的病例中发现DDS为13或更高。在70岁以上的老年人中，95%以上的患者的总DDS ≥ 13。总DDS与颈椎活动度呈显著负相关（r=-0.46，p < 0.0001），男性（r=-0.52，p < 0.0001）和女性（r=-0.40，p < 0.0001）均如此。这项对健康受试者颈椎MRI数据的大规模横断面分析表明，颈椎间盘退变随着年龄的增长而进展，并与活动度降低相关。
The aim of this study was to establish the age-related changes and gender-specific differences of cervical disc degeneration using magnetic resonance image (MRI) and to evaluate the correlation between the severity of cervical disc degeneration and mobility in asymptomatic subjects. A total of 1,211 relatively healthy volunteers (606 males and 605 females, mean age 49.5 years) without neurological symptoms underwent MRI. At least 100 males and 100 females in each decade of life between the 20 s and the 70 s were included. This study was part of a larger project and used some previously published data. Cervical disc degeneration was defined according to the modified Pfirrmann classification system. A total disc degeneration score (DDS) was calculated by the summation of individual Pfirrmann scores from C2/C3 to C7/T1. Cervical range of motion (ROM) was measured by radiograph. The total DDS increased gradually with increasing age in both genders. DDSs were lower in females than in males in all decades. A DDS of 13 or more was found in more than half the cases in the 40 s or older age groups. The total DDS was 13 or more in over 95% of the cases in the 70 s age group. The total DDS was significantly and negatively correlated with cervical ROM overall (r= − 0.46,p< 0.0001) and in both men (r= − 0.52,p< 0.0001) and women (r= − 0.40,p< 0.0001). This large-scale cross-sectional analysis of cervical spine MRI data in healthy subjects demonstrated that cervical disc degeneration progresses with age, and is correlated with a reduction in mobility.
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影响因子：
2.8
作者：
Okada, Eijiro;Matsumoto, Morio;Takahata, Takeshi
通讯作者：
Takahata, Takeshi
影响因子：
2.8
作者：
Wilke, Hans-Joachim;Rohlmann, Friederike;Kettler, Annette
通讯作者：
Kettler, Annette
影响因子：
3
作者：
Nakashima, Hiroaki;Yukawa, Yasutsugu;Kato, Fumihiko
通讯作者：
Kato, Fumihiko
影响因子：
3
作者：
Okada, Eijiro;Matsumoto, Morio;Takahata, Takeshi
通讯作者：
Takahata, Takeshi
无症状志愿者二十年纵向随访 MRI 研究：颈椎排列对椎间盘退变的影响
影响因子：
1.9
作者：
Eijiro Okada;Kenshi Daimon;H. Fujiwara;Y. Nishiwaki;K. Nojiri;Masahiko Watanabe;H. Katoh;K. Shimizu;Hiroko Ishihama;Nobuyuki Fujita;T. Tsuji;M. Nakamura;M. Matsumoto;Kota Watanabe
通讯作者：
Kota Watanabe