Interleukin-5 and IL-5 receptor in health and diseases.
Interleukin-5 and IL-5 receptor in health and diseases.
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健康与疾病中的白介素5和IL-5受体。
DOI：
10.2183/pjab.87.463
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Takatsu K
中科院分区：
文献类型：
--
作者：
Takatsu K
虽然白细胞介素-5（IL-5）最初通过其在体外支持小鼠B细胞生长和终末分化为抗体分泌细胞的能力来鉴定，但重组IL-5对各种靶细胞（包括B细胞、嗜酸性粒细胞和嗜碱性粒细胞）发挥多效性活性。IL-5由造血和非造血细胞产生，包括T细胞、粒细胞和天然辅助细胞。IL-5通过包含IL-5特异性α和共同β亚基的受体发挥其增殖和分化作用。活化B细胞中IL-5 R α的表达受转录因子复合物（包括E12、E47、Sp1、c/EBPβ和Oct 2）调节。IL-5信号通过JAK-STAT、Btk和Ras/Raf-ERK信号传导途径转导，并导致维持B细胞和嗜酸性粒细胞的存活和功能。体内IL-5的过表达显著增加嗜酸性粒细胞和B细胞的数量，而缺乏IL-5或IL-5受体的功能基因的小鼠在B细胞和嗜酸性粒细胞谱系中显示出许多发育和功能障碍。在人类中，IL-5的生物学效应最好表征为嗜酸性粒细胞。近年来，我们对嗜酸性粒细胞的发展和激活以及嗜酸性粒细胞依赖性炎症性疾病的发病机制的理解有所扩展，这导致了治疗选择的进步。静脉注射人源化抗IL-5单克隆抗体可降低轻度哮喘患者的基线支气管粘膜嗜酸性粒细胞;为抑制IL-5治疗哮喘和其他过敏性疾病的策略提供了重要的启示。
While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells including B cells, eosinophils, and basophils. IL-5 is produced by both hematopoietic and non-hematopoietic cells including T cells, granulocytes, and natural helper cells. IL-5 exerts its effects for proliferation and differentiation via receptors that comprise an IL-5-specific α and common β-subunit. IL-5Rα expression in activated B cells is regulated by a complex of transcription factors including E12, E47, Sp1, c/EBPβ, and Oct2. IL-5 signals are transduced through JAK–STAT, Btk, and Ras/Raf-ERK signaling pathways and lead to maintenance of survival and functions of B cells and eosinophils. Overexpression of IL-5 in vivo significantly increases eosinophils and B cells in number, while mice lacking a functional gene for IL-5 or IL-5 receptor display a number of developmental and functional impairments in B cells and eosinophil lineages. In humans, the biologic effects of IL-5 are best characterized for eosinophils. The recent expansion in our understanding of eosinophil development and activation and pathogenesis of eosinophil-dependent inflammatory diseases has led to advance in therapeutic options. Intravenous administration of humanized anti-IL-5 monoclonal antibody reduces baseline bronchial mucosal eosinophils in mild asthma; providing important implications for strategies that inhibit the actions of IL-5 to treat asthma and other allergic diseases.
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SPRSED-1负调节过敏原诱导的气道嗜酸性粒细胞和反应性过高。
影响因子：
15.3
作者：
Inoue, H;Kato, R;Fukuyama, S;Nonami, A;Taniguchi, KI;Matsunmoto, K;Nakano, T;Tsuda, M;Matsumura, M;Kubo, M;Ishikawa, F;Moon, BG;Takatsu, K;Nakanishi, Y;Yoshimura, A
通讯作者：
Yoshimura, A
DOI：
10.1073/pnas.84.13.4581
发表时间：
1987-07-01
影响因子：
11.1
作者：
HARADA, N;TAKAHASHI, T;TAKATSU, K
通讯作者：
TAKATSU, K
影响因子：
64.8
作者：
Galli, Stephen J.;Tsai, Mindy;Piliponsky, Adrian M.
通讯作者：
Piliponsky, Adrian M.
影响因子：
4.4
作者：
Hirano, M;Kikuchi, Y;Takatsu, K
通讯作者：
Takatsu, K
影响因子：
14.2
作者：
Busse, William W.;Katial, Rohit;Molfino, Nestor A.
通讯作者：
Molfino, Nestor A.